The How and Why of Identifying the Hair Cell Mechano-electrical Transduction Channel

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2014 Sep 23

PMID 25241775

Citations 9

Authors

Thomas Effertz

Alexandra L Scharr

Anthony J Ricci

Affiliations

Soon will be listed here.

Abstract

Identification of the auditory hair cell mechano-electrical transduction (hcMET) channel has been a major focus in the hearing research field since the 1980s when direct mechanical gating of a transduction channel was proposed (Corey and Hudspeth J Neurosci 3:962-976, 1983). To this day, the molecular identity of this channel remains controversial. However, many of the hcMET channel's properties have been characterized, including pore properties, calcium-dependent ion permeability, rectification, and single channel conductance. At this point, elucidating the molecular identity of the hcMET channel will provide new tools for understanding the mechanotransduction process. This review discusses the significance of identifying the hcMET channel, the difficulties associated with that task, as well as the establishment of clear criteria for this identification. Finally, we discuss potential candidate channels in light of these criteria.

Citing Articles

Structures of the TMC-1 complex illuminate mechanosensory transduction.

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Mechanotransduction in mammalian sensory hair cells.

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In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.

Wang Y, Steele C, Puria S, Ricci A Commun Biol. 2021; 4(1):958.

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Rat Auditory Inner Hair Cell Mechanotransduction and Stereociliary Membrane Diffusivity Are Similarly Modulated by Calcium.

George S, Steele C, Ricci A iScience. 2020; 23(12):101773.

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Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.

Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E Elife. 2018; 7.

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