Mitochondrial Dynamics and Inheritance During Cell Division, Development and Disease

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2014 Sep 20

PMID 25237825

Citations 485

Authors

Prashant Mishra

David C Chan

Affiliations

Soon will be listed here.

Abstract

During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features - including their own genome and a maternal mode of germline transmission - that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.

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References

Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P . Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol. 2012; 14(2):177-85. DOI: 10.1038/ncb2422. View

Lazzarino D, Boldogh I, Smith M, Rosand J, Pon L . Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol Biol Cell. 1994; 5(7):807-18. PMC: 301098. DOI: 10.1091/mbc.5.7.807. View

Rossanese O, Reinke C, Bevis B, Hammond A, Sears I, OConnor J . A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J Cell Biol. 2001; 153(1):47-62. PMC: 2185536. DOI: 10.1083/jcb.153.1.47. View

Martins de Brito O, Scorrano L . Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008; 456(7222):605-10. DOI: 10.1038/nature07534. View

Chen H, Chomyn A, Chan D . Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem. 2005; 280(28):26185-92. DOI: 10.1074/jbc.M503062200. View

Boldogh I, Ramcharan S, Yang H, Pon L . A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division. Mol Biol Cell. 2004; 15(9):3994-4002. PMC: 515334. DOI: 10.1091/mbc.e04-01-0053. View

He Y, Wu J, Dressman D, Iacobuzio-Donahue C, Markowitz S, Velculescu V . Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature. 2010; 464(7288):610-4. PMC: 3176451. DOI: 10.1038/nature08802. View

Kang J, Tian J, Pan P, Zald P, Li C, Deng C . Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell. 2008; 132(1):137-48. PMC: 2259239. DOI: 10.1016/j.cell.2007.11.024. View

Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N . Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun. 2005; 339(2):485-9. DOI: 10.1016/j.bbrc.2005.11.044. View

10.

Hoepfner D, van den Berg M, Philippsen P, Tabak H, Hettema E . A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J Cell Biol. 2001; 155(6):979-90. PMC: 2150915. DOI: 10.1083/jcb.200107028. View

11.

Boynton J, Harris E, Burkhart B, Lamerson P, Gillham N . Transmission of mitochondrial and chloroplast genomes in crosses of Chlamydomonas. Proc Natl Acad Sci U S A. 1987; 84(8):2391-5. PMC: 304657. DOI: 10.1073/pnas.84.8.2391. View

12.

Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang J . Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A. 2006; 103(28):10793-8. PMC: 1502310. DOI: 10.1073/pnas.0602493103. View

13.

Hayashi J, Ohta S, Kikuchi A, Takemitsu M, Goto Y, Nonaka I . Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci U S A. 1991; 88(23):10614-8. PMC: 52980. DOI: 10.1073/pnas.88.23.10614. View

14.

Frank S, Gaume B, Bergmann-Leitner E, Leitner W, Robert E, Catez F . The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001; 1(4):515-25. DOI: 10.1016/s1534-5807(01)00055-7. View

15.

Payne B, Wilson I, Yu-Wai-Man P, Coxhead J, Deehan D, Horvath R . Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet. 2012; 22(2):384-90. PMC: 3526165. DOI: 10.1093/hmg/dds435. View

16.

Rambold A, Kostelecky B, Elia N, Lippincott-Schwartz J . Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A. 2011; 108(25):10190-5. PMC: 3121813. DOI: 10.1073/pnas.1107402108. View

17.

Twig G, Elorza A, Molina A, Mohamed H, Wikstrom J, Walzer G . Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008; 27(2):433-46. PMC: 2234339. DOI: 10.1038/sj.emboj.7601963. View

18.

Swayne T, Zhou C, Boldogh I, Charalel J, McFaline-Figueroa J, Thoms S . Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast. Curr Biol. 2011; 21(23):1994-9. PMC: 3237857. DOI: 10.1016/j.cub.2011.10.019. View

19.

Berger K, Sogo L, Yaffe M . Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol. 1997; 136(3):545-53. PMC: 2134291. DOI: 10.1083/jcb.136.3.545. View

20.

Yoshii S, Kishi C, Ishihara N, Mizushima N . Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem. 2011; 286(22):19630-40. PMC: 3103342. DOI: 10.1074/jbc.M110.209338. View