Bone Marrow Cell-based Regenerative Therapy for Liver Cirrhosis

Overview

Journal World J Methodol

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2014 Sep 20

PMID 25237624

Citations 5

Authors

Takafumi Saito

Kyoko Tomita

Hiroaki Haga

Kazuo Okumoto

Yoshiyuki Ueno

Affiliations

Soon will be listed here.

Abstract

Bone marrow cells are capable of differentiation into liver cells. Therefore, transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue. Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis, and improvement of liver function parameters has been demonstrated. In this review, we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis, as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.

Citing Articles

Autologous bone marrow stem cell transplantation via the hepatic artery for the treatment of hepatitis B virus-related cirrhosis: a PRISMA-compliant meta-analysis based on the Chinese population.

Sun A, Gao W, Xiao T Stem Cell Res Ther. 2020; 11(1):104.

PMID: 32138750 PMC: 7059376. DOI: 10.1186/s13287-020-01627-5.

Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis.

Zhang L, Zhou D, Li J, Yan X, Zhu J, Xiao P Med Sci Monit. 2019; 25:7182-7190.

PMID: 31550244 PMC: 6775794. DOI: 10.12659/MSM.916428.

Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases.

Kim D, Cho G, Han C, Park D, Park H, Woo D Tissue Eng Regen Med. 2019; 14(6):653-665.

PMID: 30603518 PMC: 6171672. DOI: 10.1007/s13770-017-0093-7.

Mesenchymal stem cell therapy for cirrhosis: Present and future perspectives.

Eom Y, Kim G, Baik S World J Gastroenterol. 2015; 21(36):10253-61.

PMID: 26420953 PMC: 4579873. DOI: 10.3748/wjg.v21.i36.10253.

Autologous mobilized peripheral blood CD34(+) cell infusion in non-viral decompensated liver cirrhosis.

Sharma M, Rao P, Sasikala M, Kuncharam M, Reddy C, Gokak V World J Gastroenterol. 2015; 21(23):7264-71.

PMID: 26109814 PMC: 4476889. DOI: 10.3748/wjg.v21.i23.7264.

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