Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases

Overview

Journal Tissue Eng Regen Med

Date 2019 Jan 4

PMID 30603518

Citations 4

Authors

Dongkyu Kim

Gun-Sik Cho

Choongseong Han

Dong-Hyuk Park

Hee-Kyung Park

Dong-Hun Woo

Jong-Hoon Kim

Affiliations

Soon will be listed here.

Abstract

Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.

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