Association Between the Proportion of Dominant Follicles and Oocyte Developmental Competence

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2014 Sep 18

PMID 25227692

Citations 5

Authors

Yi Li

Rui-Qi Li

Song-Bang Ou

Ling Ren

Ning-Feng Zhang

Li-Na Wei

Qing-Xue Zhang

Dong-Zi Yang

Affiliations

Soon will be listed here.

Abstract

Purpose: To explore the optimal timing for hCG triggering by investigating the impact of different proportion of dominant follicles on the oocyte developmental competence.

Methods: One hundred ninety-eight infertile women were divided into three groups according to the proportion of dominant follicles on hCG day: (1) low: <15% (n = 66); (2) middle: 15-27% (n = 66); (3) high: >27% (n = 66). The grouping criteria were the bottom and top tertiles of the proportion of dominant follicles.

Results: The gonadotropin dosage, duration and maximum follicle diameter in the low proportion group were lower than those in the middle and high proportion groups. Oocyte maturation and the abnormal fertilization rate in the low proportion group were lower than those in the middle and high proportion groups. The normal fertilization rate did not differ among the three groups. The cleavage rate and number of transferable embryos in the low proportion group were significantly higher than those in the high proportion group. The high-quality embryo rate, implantation rate, and pregnancy rate in the low proportion group were significantly higher than those in the middle and high proportion groups.

Conclusions: A high proportion of dominant follicles are closely associated with impaired oocyte developmental competence and low pregnancy rate. These findings suggest that follicular overgrowth induced by delayed hCG triggering may undermine oocyte developmental competence and the proportion of dominant follicles may be a potential parameters for hCG triggering.

Citing Articles

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Meta-analysis of trigger timing in normal responders undergoing GnRH antagonist ovarian hyperstimulation protocol.

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Letrozole cotreatment improves the follicular output rate in high-body-mass-index women with polycystic ovary syndrome undergoing IVF treatment.

Liu Y, Lin J, Shen X, Zhu Q, Kuang Y Front Endocrinol (Lausanne). 2023; 14:1072170.

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Increasing dominant follicular proportion negatively associated with good clinical outcomes in normal ovarian responders using the depot GnRH agonist protocol: a large-sample retrospective analysis.

Su H, Lai Y, Li J, Liao T, Ji L, Hu X J Ovarian Res. 2022; 15(1):44.

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Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?.

Kahraman S, Pirkevi Cetinkaya C, Cetinkaya M, Tufekci M, Gokhan Ekmekci C, Montag M Reprod Biol Endocrinol. 2018; 16(1):69.

PMID: 30031399 PMC: 6054838. DOI: 10.1186/s12958-018-0388-0.

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