Prolonged Gonadotropin Stimulation is Associated with Decreased ART Success

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2010 Sep 8

PMID 20821043

Citations 10

Authors

Meleen Chuang

Athena Zapantis

Martina Taylor

Sangita K Jindal

Genevieve S Neal-Perry

Harry J Lieman

Alex Joel Polotsky

Affiliations

Soon will be listed here.

Abstract

Purpose: to evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART.

Methods: all IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed.

Results: out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis.

Conclusions: prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.

Citing Articles

The gonadotropins starting dose calculator, which can be adjusted the target number of oocytes and stimulation duration days to achieve individualized controlled ovarian stimulation in Japanese patients.

Kobanawa M Reprod Med Biol. 2023; 22(1):e12499.

PMID: 36699956 PMC: 9853467. DOI: 10.1002/rmb2.12499.

"Short agonist stop" protocol, an ovarian stimulation for poor responders in fertilization (IVF): A pilot study.

Mauries C, Ranisavljevic N, Mollevi C, Brunet C, Hamamah S, Brouillet S Front Endocrinol (Lausanne). 2022; 13:1056520.

PMID: 36465628 PMC: 9714551. DOI: 10.3389/fendo.2022.1056520.

Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time.

Zhao X, Zhang X, Wu S, Tan J Front Endocrinol (Lausanne). 2022; 13:862500.

PMID: 35957813 PMC: 9361069. DOI: 10.3389/fendo.2022.862500.

Ovarian Stimulation in Assisted Reproductive Technology Cycles for Varied Patient Profiles: An Indian Perspective.

Jirge P, Patil M, Gutgutia R, Shah J, Govindarajan M, Roy V J Hum Reprod Sci. 2022; 15(2):112-125.

PMID: 35928474 PMC: 9345274. DOI: 10.4103/jhrs.jhrs_59_22.

Stimulation Duration in Patients with Early Oocyte Maturation Triggering Criteria Does Not Impact IVF-ICSI Outcomes.

Stout S, Dabi Y, Dupont C, Selleret L, Touboul C, Chabbert-Buffet N J Clin Med. 2022; 11(9).

PMID: 35566454 PMC: 9102252. DOI: 10.3390/jcm11092330.

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