Animal Models of Psychosis: Current State and Future Directions

Overview

Journal Curr Behav Neurosci Rep

Specialty Social Sciences

Date 2014 Sep 13

PMID 25215267

Citations 29

Authors

Alexandra D Forrest

Carlos A Coto

Steven J Siegel

Affiliations

Soon will be listed here.

Abstract

Psychosis is an abnormal mental state characterized by disorganization, delusions and hallucinations. Animal models have become an increasingly important research tool in the effort to understand both the underlying pathophysiology and treatment of psychosis. There are multiple animal models for psychosis, with each formed by the coupling of a manipulation and a measurement. In this manuscript we do not address the diseases of which psychosis is a prominent comorbidity. Instead, we summarize the current state of affairs and future directions for animal models of psychosis. To accomplish this, our manuscript will first discuss relevant behavioral and electrophysiological measurements. We then provide an overview of the different manipulations that are combined with these measurements to produce animal models. The strengths and limitations of each model will be addressed in order to evaluate its cross-species comparability.

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