The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview

Overview

Journal Adv Neurobiol

Publisher Springer

Date 2024 Nov 19

PMID 39562449

Authors

Lindsey M Crown

Robert E Featherstone

Janet L Sobell

Krishna Parekh

Steven J Siegel

Affiliations

Soon will be listed here.

Abstract

Event-related potentials (ERPs) are small voltage changes in the brain that reliably occur in response to auditory or visual stimuli. ERPs have been extensively studied in both humans and animals to identify biomarkers, test pharmacological agents, and generate testable hypotheses about the physiological and genetic basis of schizophrenia. In this chapter, we discuss how ERPs are generated and recorded as well as review canonical ERP components in the context of schizophrenia research in humans. We then discuss what is known about rodent homologs of these components and how they are altered in common pharmacologic and genetic manipulations used in preclinical schizophrenia research. This chapter will also explore the relationship of ERPs to leading hypotheses about the pathophysiology of schizophrenia. We conclude with an evaluation of both the utility and limitations of ERPs in schizophrenia research and offer recommendations of future directions that may be beneficial to the field.

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