Recombination-mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection

Overview

Journal Retrovirology

Publisher Biomed Central

Specialty Microbiology

Date 2014 Sep 13

PMID 25212771

Citations 22

Authors

Adam John Ritchie

Fangping Cai

Nicola M G Smith

Sheri Chen

Hongshuo Song

Simon Brackenridge

Salim S Abdool Karim

Bette T Korber

Andrew J McMichael

Feng Gao

Nilu Goonetilleke

Affiliations

Soon will be listed here.

Abstract

Background: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.

Results: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.

Conclusions: Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

Citing Articles

Multiple third-generation recombinants formed by CRF55_01B and CRF07_BC in newly diagnosed HIV-1 infected patients in Shenzhen city, China.

Jiao Y, An M, Zhang N, Zhang H, Zheng C, Chen L Virol J. 2024; 21(1):306.

PMID: 39593171 PMC: 11590514. DOI: 10.1186/s12985-024-02563-z.

Identification of the Near Full-Length Genome of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant in Hebei Province, China.

Geng H, Liu B, Liu Y, Chen S, Shi H, Fan W AIDS Res Hum Retroviruses. 2024; 40(7):449-453.

PMID: 38407970 PMC: 11295790. DOI: 10.1089/AID.2023.0119.

Elevated HIV Viral Load is Associated with Higher Recombination Rate In Vivo.

Romero E, Feder A Mol Biol Evol. 2024; 41(1).

PMID: 38197289 PMC: 10777272. DOI: 10.1093/molbev/msad260.

Identification of a HIV-1 circulating BF1 recombinant form (CRF75_BF1) of Brazilian origin that also circulates in Southwestern Europe.

Bacque J, Delgado E, Gil H, Ibarra S, Benito S, Garcia-Arata I Front Microbiol. 2023; 14:1301374.

PMID: 38125564 PMC: 10731470. DOI: 10.3389/fmicb.2023.1301374.

Elevated HIV viral load is associated with higher recombination rate .

Romero E, Feder A bioRxiv. 2023; .

PMID: 37873119 PMC: 10592651. DOI: 10.1101/2023.05.05.539643.

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