High Prevalence of Lipid Transfer Protein Sensitization in Apple Allergic Patients with Systemic Symptoms

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Sep 12

PMID 25210741

Citations 9

Authors

Francisca Gomez

Ana Aranda

Paloma Campo

Araceli Diaz-Perales

Natalia Blanca-Lopez

James Perkins

Maria Garrido

Miguel Blanca

Cristobalina Mayorga

Maria Jose Torres

Affiliations

Soon will be listed here.

Abstract

Background: Apple allergy manifests as two main groups of clinical entities reflecting different patterns of allergen sensitization: oral allergy syndrome (OAS) and generalized symptoms (GS).

Objective: We analysed the sensitization profile to a wide panel of different components of food allergens (rMal d 1, Mal d 2, rMal d 3, rMal d 4, rPru p 3, rBet v 1 and Pho d 2) for a population of Mediterranean patients with OAS and GS to apple.

Methods: Patients (N = 81) with a history of apple allergy that could be confirmed by positive prick-prick test and/or double-blind-placebo-controlled food challenge (DBPCFC), were included. Skin prick test (SPT) and ELISA were performed using a panel of inhalant, fruit and nut allergens. ELISA and ELISA inhibition studies were performed in order to analyse the sensitization patterns.

Results: Thirty-five cases (43.2%) had OAS and 46 (56.8%) GS. SPT showed a significantly higher number of positive results with peach, cherry and hazelnut in those with GS. ELISA showed a significantly high percentage of positive cases to rMal d 3, rMal d 4, rPru p 3 and Pho d 2 in patients with OAS and GS compared to controls, and to rBet v 1 in patients with OAS vs controls and between OAS and GS patients. Three different patterns of recognition were detected: positive to LTP (rMal d 3 or rPru p 3), positive to profilin (rMal d 4 and Pho d 2), or positive to both. There were also patients with rMal d 1 recognition who showed cross-reactivity to rBet v 1.

Conclusion: In an apple allergy population with a high incidence of pollinosis different patterns of sensitization may occur. LTP is most often involved in those with GS. Profilin, though more prevalent in patients with OAS, has been shown to sensitise patients with both types of symptoms.

Citing Articles

Profiles of apple allergen components and its diagnostic value in Northern China.

Wang X, Chen L, Lan T, Wang H, Wang X Front Med (Lausanne). 2024; 11:1388766.

PMID: 38938380 PMC: 11208676. DOI: 10.3389/fmed.2024.1388766.

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China.

Wang X, Chen L, Ding J, Wang H, Wang X J Asthma Allergy. 2023; 16:1241-1250.

PMID: 38022747 PMC: 10656847. DOI: 10.2147/JAA.S427764.

Apple allergy: Causes and factors influencing fruits allergenic properties-Review.

Siekierzynska A, Piasecka-Kwiatkowska D, Myszka A, Burzynska M, Sozanska B, Sozanski T Clin Transl Allergy. 2021; 11(4):e12032.

PMID: 34123364 PMC: 8171779. DOI: 10.1002/clt2.12032.

The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area.

Scheurer S, van Ree R, Vieths S Curr Allergy Asthma Rep. 2021; 21(2):7.

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