In Vivo Anti-fatigue Activity of Sufu with Fortification of Isoflavones

Overview

Journal Pharmacogn Mag

Publisher Sage Publications

Date 2014 Sep 12

PMID 25210327

Citations 7

Authors

Yunxian Liu

Yun Zhou

Satoru Nirasawa

Eizo Tatsumi

Yongqiang Cheng

Lite Li

Affiliations

Soon will be listed here.

Abstract

Background: Sufu is a traditional Chinese fermented soybean food. Isoflavones are abundant in soybean and products incorporated with isoflavones exert many health benefits. The aim of this study was to investigate anti-fatigue effect of sufu fortified with isoflavones.

Materials And Methods: In vivo anti-fatigue activity of sufu with fortification of isoflavones (IF) was investigated in this study via exhaustive swimming test using ICR mice and determination of biochemical parameters. Factors relating to fatigue, including hepatic glycogen, blood lactic acid (BLA), blood urea nitrogen (BUN) were determined. The isoflavone composition in the IF sufu was also determined to explore the anti-fatigue activity of isoflavones.

Results: During fermentation, isoﬂavone glucosides were converted into aglycones and both sufu with and without fortification of IF prolonged the exhaustive swimming time of ICR mice. Intake of sufu also increased the hepatic glycogen content, while it decreased the levels of both the blood lactic acid (BLA) and blood urea nitrogen (BUN) content. A dose-response relationship was observed in both exhaustive swimming and BLA clearance test, with medium dose (1%) fortification of IF revealing the highest activity.

Conclusion: IF sufu could possess high anti-fatigue activity.

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