Rational Modification of Oligoarginine for Highly Efficient SiRNA Delivery: Structure-activity Relationship and Mechanism of Intracellular Trafficking of SiRNA

Overview

Journal Nanomedicine

Publisher Elsevier

Specialties Biomedical Engineering
Biotechnology

Date 2014 Sep 7

PMID 25193363

Citations 12

Authors

Dafeng Chu

Wen Xu

Ran Pan

Yong Ding

Weiping Sui

P Chen

Affiliations

Soon will be listed here.

Abstract

From The Clinical Editor: This study present a novel cell penetrating peptide-based siRNA delivery system utilizing modified oligo-arginine demonstrating a successful siRNA delivery approach.

Citing Articles

Cell Penetrability of a γ-Crystallin Peptide Fragment from the Discarded Cataractous Eye Emulsion.

Chowdhury P, Ojha A, Bhowmik S, Halder K, Sabnam K, Santra S ACS Omega. 2024; 9(13):14840-14848.

PMID: 38585046 PMC: 10993246. DOI: 10.1021/acsomega.3c07665.

Non-terminal conjugation of small interfering RNAs with spermine improves duplex binding and serum stability with position-specific incorporation.

Koyasu K, Chandela A, Ueno Y RSC Adv. 2023; 13(36):25169-25181.

PMID: 37622021 PMC: 10445083. DOI: 10.1039/d3ra04918c.

Protein and Peptide-Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins.

Zhang L, Yao L, Zhao F, Yu A, Zhou Y, Wen Q Adv Healthc Mater. 2023; 12(25):e2300473.

PMID: 37537383 PMC: 11468125. DOI: 10.1002/adhm.202300473.

Membrane Internalization Mechanisms and Design Strategies of Arginine-Rich Cell-Penetrating Peptides.

Hao M, Zhang L, Chen P Int J Mol Sci. 2022; 23(16).

PMID: 36012300 PMC: 9409441. DOI: 10.3390/ijms23169038.

Multistage pH-responsive codelivery liposomal platform for synergistic cancer therapy.

Zhao T, Liang C, Zhao Y, Xue X, Ma Z, Qi J J Nanobiotechnology. 2022; 20(1):177.

PMID: 35366888 PMC: 8976966. DOI: 10.1186/s12951-022-01383-z.