Association of Obesity with Asthma Severity, Control and Quality of Life

Overview

Journal Tanaffos

Specialty Pulmonary Medicine

Date 2014 Sep 6

PMID 25191399

Citations 10

Authors

Sonia Maalej

Zouhour Yaacoub

Radhouane Fakhfekh

Sadok Yaalaoui

Ali Ben Kheder

Ikram Drira

Affiliations

Soon will be listed here.

Abstract

Background: The association between asthma and obesity is becoming increasingly established but the mechanism that might explain the observed differences in asthma severity, control and quality of life between obese and non-obese adult asthmatics is not clear. THE PURPOSE OF THIS STUDY WAS: 1) to determine asthma severity, control and quality of life in obese asthmatics and 2) to explore, according to the body mass index (BMI), the systemic inflammatory state of asthmatic people.

Materials And Methods: A cross-sectional study was conducted between 2009 and 2010. Two hundred adult asthmatic patients were included. Data analysis consisted of univariate analysis with chi-square comparison test followed by a multivariate logistic regression.

Results: Obesity worsens the severity of asthma. This finding was more strongly observed among women than men. Obesity and overweight are associated with a poorer control of asthma. According to BMI, obese asthmatics had 6 times more frequent emergency visits, 5 times more frequent hospitalizations for asthma related complaints, increased missed work days and greater dose of inhaled corticosteroids (1025µg/day vs. 759µg/day of beclometasone equivalent). Mean serum level of C-reactive protein (CRP) and leptin was significantly correlated with asthma severity based on GINA classification (5.75 vs. 2.81 mg/l; 20.5 vs. 5.38 ng/ml; respectively).

Conclusion: In summary, it appears that obesity is significantly associated with a greater asthma severity and a poorer asthma control and quality of life. Chronic systemic inflammation state may explain the relationship between obesity and asthma.

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References

Juniper E, Guyatt G, Epstein R, Ferrie P, Jaeschke R, Hiller T . Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax. 1992; 47(2):76-83. PMC: 463574. DOI: 10.1136/thx.47.2.76. View

Loerbroks A, Apfelbacher C, Amelang M, Sturmer T . Obesity and adult asthma: potential effect modification by gender, but not by hay fever. Ann Epidemiol. 2007; 18(4):283-9. DOI: 10.1016/j.annepidem.2007.11.001. View

Juniper E, OByrne P, Guyatt G, Ferrie P, King D . Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999; 14(4):902-7. DOI: 10.1034/j.1399-3003.1999.14d29.x. View

Lessard A, Turcotte H, Cormier Y, Boulet L . Obesity and asthma: a specific phenotype?. Chest. 2008; 134(2):317-323. DOI: 10.1378/chest.07-2959. View

Dixon A, Shade D, Cohen R, Skloot G, Holbrook J, Smith L . Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma. 2006; 43(7):553-8. DOI: 10.1080/02770900600859123. View

Chen Y, Dales R, Tang M, Krewski D . Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol. 2002; 155(3):191-7. DOI: 10.1093/aje/155.3.191. View

Pelegrino N, Faganello M, Sanchez F, Padovani C, Godoy I . [Relationship between body mass index and asthma severity in adults]. J Bras Pneumol. 2008; 33(6):641-6. DOI: 10.1590/s1806-37132007000600006. View

Saint-Pierre P, Bourdin A, Chanez P, Daures J, Godard P . Are overweight asthmatics more difficult to control?. Allergy. 2005; 61(1):79-84. DOI: 10.1111/j.1398-9995.2005.00953.x. View

Elamin E . Asthma and obesity: a real connection or a casual association?. Chest. 2004; 125(6):1972-4. DOI: 10.1378/chest.125.6.1972. View

10.

Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F . Body mass index and asthma severity in the National Asthma Survey. Thorax. 2007; 63(1):14-20. DOI: 10.1136/thx.2007.082784. View

11.

de Marco R, Marcon A, Jarvis D, Accordini S, Almar E, Bugiani M . Prognostic factors of asthma severity: a 9-year international prospective cohort study. J Allergy Clin Immunol. 2006; 117(6):1249-56. DOI: 10.1016/j.jaci.2006.03.019. View

12.

Kim S, Camargo Jr C . Sex-race differences in the relationship between obesity and asthma: the behavioral risk factor surveillance system, 2000. Ann Epidemiol. 2003; 13(10):666-73. DOI: 10.1016/s1047-2797(03)00054-1. View

13.

Lavoie K, Bacon S, Labrecque M, Cartier A, Ditto B . Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med. 2005; 100(4):648-57. DOI: 10.1016/j.rmed.2005.08.001. View

14.

Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F . Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol. 2004; 114(2):254-9. DOI: 10.1016/j.jaci.2004.03.053. View

15.

Clerisme-Beaty E, Karam S, Rand C, Patino C, Bilderback A, Riekert K . Does higher body mass index contribute to worse asthma control in an urban population?. J Allergy Clin Immunol. 2009; 124(2):207-12. PMC: 2733240. DOI: 10.1016/j.jaci.2009.05.034. View

16.

Tantisira K, Weiss S . Complex interactions in complex traits: obesity and asthma. Thorax. 2001; 56 Suppl 2:ii64-73. PMC: 1765987. View

17.

Considine R, Sinha M, Heiman M, Kriauciunas A, STEPHENS T, Nyce M . Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996; 334(5):292-5. DOI: 10.1056/NEJM199602013340503. View

18.

Mosen D, Schatz M, Magid D, Camargo Jr C . The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008; 122(3):507-11.e6. DOI: 10.1016/j.jaci.2008.06.024. View