Evaluation of Impairment of Health Related Quality of Life in Asthma: Development of a Questionnaire for Use in Clinical Trials

Overview

Journal Thorax

Date 1992 Feb 1

PMID 1549827

Citations 317

Authors

E F Juniper

G H Guyatt

R S Epstein

P J Ferrie

R Jaeschke

T K Hiller

Affiliations

Soon will be listed here.

Abstract

Background: In the past only physiological and clinical outcomes have been used to assess the effect of asthma interventions and the effect of the intervention on the lives of the patients has not been determined. The objective of this study was to assess health related impairment of quality of life in adult asthmatic patients and to develop a questionnaire for measuring quality of life in clinical trials in asthma.

Methods: Impairment of quality of life in adults with asthma was evaluated from structured interviews in which patients were asked to identify the parts of their daily lives affected by asthma. On the basis of these results, an asthma quality of life questionnaire was developed in an interviewer and self administered form and tested for comprehension and acceptability. A total of 150 adults with asthma and with a wide range of airway hyperresponsiveness were enrolled from previous clinical trials, local asthma clinics, and notices in the media.

Results: Areas of quality of life impairment included symptoms classically associated with asthma, responses to environmental stimuli, the need to avoid these stimuli, limitation of activities, and emotional dysfunction. Areas of impairment were similar across strata of airway hyperresponsiveness, age, and treatment requirements and between sexes, thus allowing a single questionnaire suitable for all adults with asthma to be developed. The questionnaire contains 32 items and takes 5-10 minutes to administer; in the pretesting it was shown to be acceptable to a wide range of patients.

Conclusions: The questionnaire includes areas of quality of life impairment that are important to adult asthmatic patients. It has been designed to be responsive to within subject change and therefore may be used as a measure of outcome in clinical trials in asthma.

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References

Guyatt G, Mitchell A, Irvine E, Singer J, Williams N, Goodacre R . A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology. 1989; 96(3):804-10. View

Jaeschke R, Singer J, Guyatt G . A comparison of seven-point and visual analogue scales. Data from a randomized trial. Control Clin Trials. 1990; 11(1):43-51. DOI: 10.1016/0197-2456(90)90031-v. View

Guyatt G, Townsend M, Keller J, Singer J . Should study subjects see their previous responses: data from a randomized control trial. J Clin Epidemiol. 1989; 42(9):913-20. DOI: 10.1016/0895-4356(89)90105-4. View

Levine M, Guyatt G, Gent M, De Pauw S, Goodyear M, Hryniuk W . Quality of life in stage II breast cancer: an instrument for clinical trials. J Clin Oncol. 1988; 6(12):1798-810. DOI: 10.1200/JCO.1988.6.12.1798. View

Guyatt G, Townsend M, BERMAN L, Pugsley S . Quality of life in patients with chronic airflow limitation. Br J Dis Chest. 1987; 81(1):45-54. DOI: 10.1016/0007-0971(87)90107-0. View

Kirshner B, Guyatt G . A methodological framework for assessing health indices. J Chronic Dis. 1985; 38(1):27-36. DOI: 10.1016/0021-9681(85)90005-0. View

Guyatt G, BERMAN L, Townsend M, Taylor D . Should study subjects see their previous responses?. J Chronic Dis. 1985; 38(12):1003-7. DOI: 10.1016/0021-9681(85)90098-0. View

Greenough A, Wood S, Morley C, Davis J . Pancuronium prevents pneumothoraces in ventilated premature babies who actively expire against positive pressure inflation. Lancet. 1984; 1(8367):1-3. DOI: 10.1016/s0140-6736(84)90177-6. View

Juniper E, Frith P, Hargreave F . Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax. 1981; 36(8):575-9. PMC: 471630. DOI: 10.1136/thx.36.8.575. View

10.

HUME K, Jones E . Bronchodilators and corticosteroids in asthma. Forced expiratory volume as an aid to diagnosis and treatment. Lancet. 1960; 2(7164):1319-22. DOI: 10.1016/s0140-6736(60)92518-6. View

11.

Juniper E, Frith P, Dunnett C, Cockcroft D, Hargreave F . Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. 1978; 33(6):705-10. PMC: 470967. DOI: 10.1136/thx.33.6.705. View

12.

Juniper E, KLINE P, Vanzieleghem M, Ramsdale E, OByrne P, Hargreave F . Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis. 1990; 142(4):832-6. DOI: 10.1164/ajrccm/142.4.832. View

13.

Josephs L, GREGG I, Mullee M, Holgate S . Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study. Am Rev Respir Dis. 1989; 140(2):350-7. DOI: 10.1164/ajrccm/140.2.350. View

14.

Guyatt G, Nogradi S, Halcrow S, Singer J, Sullivan M, Fallen E . Development and testing of a new measure of health status for clinical trials in heart failure. J Gen Intern Med. 1989; 4(2):101-7. DOI: 10.1007/BF02602348. View

15.

Stewart A, Hays R, Ware Jr J . The MOS short-form general health survey. Reliability and validity in a patient population. Med Care. 1988; 26(7):724-35. DOI: 10.1097/00005650-198807000-00007. View

16.

Guyatt G, Bombardier C, Tugwell P . Measuring disease-specific quality of life in clinical trials. CMAJ. 1986; 134(8):889-95. PMC: 1490966. View

17.

Kinsman R, LUPARELLO T, OBanion K, Spector S . Multidimensional analysis of the subjective symptomatology of asthma. Psychosom Med. 1973; 35(3):250-67. DOI: 10.1097/00006842-197305000-00008. View

18.

Hargreave F, Ryan G, Thomson N, OByrne P, Latimer K, Juniper E . Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981; 68(5):347-55. DOI: 10.1016/0091-6749(81)90132-9. View

19.

Bergner M, Bobbitt R, Carter W, Gilson B . The Sickness Impact Profile: development and final revision of a health status measure. Med Care. 1981; 19(8):787-805. DOI: 10.1097/00005650-198108000-00001. View

20.

Juniper E, Guyatt G . Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis. Clin Exp Allergy. 1991; 21(1):77-83. DOI: 10.1111/j.1365-2222.1991.tb00807.x. View