Effect of Limited Access Dressing on Hydroxyproline and Enzymatic Antioxidant Status in Nonhealing Chronic Ulcers

Overview

Journal Indian J Plast Surg

Publisher Thieme

Specialty General Surgery

Date 2014 Sep 6

PMID 25190917

Citations 6

Authors

Thittamaranahalli Muguregowda Honnegowda

Pramod Kumar

Padmanabha Udupa

Pragna Rao

Siddhartha Bhandary

Krishna Kumar Mahato

Anurag Sharan

Shreemathi S Mayya

Affiliations

Soon will be listed here.

Abstract

Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.

Materials And Method: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17).

Results: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045).

Conclusion: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.

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