Calcific Aortic Valve Disease: a Consensus Summary from the Alliance of Investigators on Calcific Aortic Valve Disease

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2014 Sep 6

PMID 25189570

Citations 156

Authors

Katherine E Yutzey

Linda L Demer

Simon C Body

Gordon S Huggins

Dwight A Towler

Cecilia M Giachelli

Marion A Hofmann-Bowman

Douglas P Mortlock

Melissa B Rogers

Mehran M Sadeghi

Elena Aikawa

Affiliations

Soon will be listed here.

Abstract

Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.

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