Probing Signal Phase in Direct Visualization of Short Transverse Relaxation Time Component (ViSTa)

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2014 Aug 27

PMID 25154599

Citations 7

Authors

Daeun Kim

Hyo Min Lee

Se-Hong Oh

Jongho Lee

Affiliations

Soon will be listed here.

Abstract

Purpose: To demonstrate the phase evolutions of direct visualization of short transverse relaxation time component (ViSTa) matches with those of myelin water.

Method: Myelin water imaging (MWI) measures short transverse signals and has been suggested as a biomarker for myelin. Recently, a new approach, ViSTa, has been proposed to acquire short T2* signals by suppressing long T1 signals. This method does not require any ill-conditioned data processing and therefore provides high-quality images. In this study, the phase of the ViSTa signal was compared with the phase of myelin water simulated by the magnetic susceptibility model of hollow cylinder.

Results: The phase evolutions of the ViSTa signal were similar to the simulated myelin water phase evolutions. When fiber orientation was perpendicular relative to the main magnetic field, both the ViSTa and the simulated myelin water phase showed large positive frequency shifts, whereas the gradient echo phase showed a slightly negative frequency shift. Additionally, the myelin water phase map generated using diffusion tensor imaging (DTI) information revealed a good match with the ViSTa phase image.

Conclusion: The results of this study support the origin of ViSTa signal as myelin water. ViSTa phase may potentially provide sensitivity to demyelination.

Citing Articles

Multicompartment imaging of the brain using a comprehensive MR imaging protocol.

Lo J, Du K, Lee D, Zeng C, Athertya J, Silva M Neuroimage. 2024; 298:120800.

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Improved magnetic resonance myelin water imaging using multi-channel denoising convolutional neural networks (MCDnCNN).

Xu G, He Y, Yu Q, He H, Zhao Z, Fan M Quant Imaging Med Surg. 2022; 12(3):1716-1737.

PMID: 35284287 PMC: 8899954. DOI: 10.21037/qims-21-404.

Myelin-Weighted Imaging Presents Reduced Apparent Myelin Water in Patients with Alzheimer's Disease.

Lim S, Lee J, Jung S, Kim B, Rhee H, Oh S Diagnostics (Basel). 2022; 12(2).

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Microscopic susceptibility anisotropy imaging.

Kaden E, Gyori N, Rudrapatna S, Barskaya I, Dragonu I, Does M Magn Reson Med. 2020; 84(5):2739-2753.

PMID: 32378746 PMC: 7402021. DOI: 10.1002/mrm.28303.

Strong diffusion gradients allow the separation of intra- and extra-axonal gradient-echo signals in the human brain.

Kleban E, Tax C, Rudrapatna U, Jones D, Bowtell R Neuroimage. 2020; 217:116793.

PMID: 32335263 PMC: 7613126. DOI: 10.1016/j.neuroimage.2020.116793.

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