Aldehyde-assisted Ruthenium(II)-catalyzed C-H Oxygenations

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2014 Aug 27

PMID 25154310

Citations 26

Authors

Fanzhi Yang

Karsten Rauch

Katharina Kettelhoit

Lutz Ackermann

Affiliations

Soon will be listed here.

Abstract

Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

Citing Articles

Boron-mediated one-pot access to salicylaldehydes -C-H hydroxylation of benzaldehydes.

Wang R, Feng X, Feng B, Chen Y RSC Adv. 2024; 14(28):19922-19925.

PMID: 38903668 PMC: 11187805. DOI: 10.1039/d4ra02994a.

Hydroxylation of Substituted Anilides with Metallaphotocatalysis.

Khatri B, Chen L, Xu D, Salter R, Lin R ACS Omega. 2024; 9(18):19982-19991.

PMID: 38737023 PMC: 11079915. DOI: 10.1021/acsomega.3c10008.

Synthesis of Benzofuro[3,2-]indol-3-one Derivatives via Dearomative (3 + 2) Cycloaddition of 2-Nitrobenzofurans and -Quinamines.

Yuan W, Zeng H, Zhang Y, Zhao J, You Y, Yin J Molecules. 2024; 29(5).

PMID: 38474676 PMC: 10934979. DOI: 10.3390/molecules29051163.

Azido-alkynylation of alkenes through radical-polar crossover.

Borrel J, Waser J Chem Sci. 2023; 14(35):9452-9460.

PMID: 37712015 PMC: 10498506. DOI: 10.1039/d3sc03309k.

Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products.

Jiang B, Dai M J Am Chem Soc. 2023; 145(34):18731-18736.

PMID: 37603855 PMC: 10472436. DOI: 10.1021/jacs.3c06031.