The Role of α-E-catenin in Cerebral Cortex Development: Radial Glia Specific Effect on Neuronal Migration

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2014 Aug 23

PMID 25147501

Citations 20

Authors

Marie-Theres Schmid

Franziska Weinandy

Michaela Wilsch-Brauninger

Wieland B Huttner

Silvia Cappello

Magdalena Gotz

Affiliations

Soon will be listed here.

Abstract

During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions (AJs) to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral cortex. Deletion at early stages resulted in severe disruption of tissue polarity due to uncoupling of AJs with the intracellular actin fibers leading to the formation of subcortical band heterotopia. Interestingly, this phenotype closely resembled the phenotype obtained by conditional RhoA deletion, both in regard to the macroscopic subcortical band heterotopia and the subcellular increase in G-actin/F-actin ratio. These data therefore together corroborate the role of the actin cytoskeleton and its anchoring to the AJs for neuronal migration disorders.

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