Effect of Recombinant Tumour Necrosis Factor on Acute Infection in Mice with Toxoplasma Gondii or Trypanosoma Cruzi

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1989 Dec 1

PMID 2514141

Citations 26

Authors

C M Black

D M Israelski

Y Suzuki

J S Remington

Affiliations

Soon will be listed here.

Abstract

Recombinant tumor necrosis factor (rTNF) has been shown to protect mice against lethal bacterial infections. We previously reported that in in vitro experiments with mouse peritoneal macrophages, rTNF inhibited intracellular multiplication of Trypanosoma cruzi but not of Toxoplasma gondii. These disparate results led us to study the effect of rTNF on the in vivo infection with these parasites. Daily administration of 0.5 and 5.0 micrograms rTNF resulted in a dose-dependent, significantly decreased time to death (p less than 0.05) in mice infected with lethal doses of T. cruzi. The same effect was found in mice infected with T. gondii and given a daily dose of 5.0 micrograms rTNF. Lower doses of rTNF did not significantly affect time to death of mice infected with either parasite.

Citing Articles

Immune response against toxoplasmosis-some recent updates RH: immune response.

Sana M, Rashid M, Rashid I, Akbar H, Gomez-Marin J, Dimier-Poisson I Int J Immunopathol Pharmacol. 2022; 36:3946320221078436.

PMID: 35227108 PMC: 8891885. DOI: 10.1177/03946320221078436.

Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu.

Silva A, Silva R, Gibaldi D, Mariante R, Dos Santos J, Resende Pereira I J Neuroinflammation. 2017; 14(1):182.

PMID: 28877735 PMC: 5588596. DOI: 10.1186/s12974-017-0952-0.

Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly.

Vallochi A, Goldberg A, Falcai A, Ramasawmy R, Kalil J, Silveira C Clin Ophthalmol. 2009; 2(4):837-48.

PMID: 19668438 PMC: 2699811. DOI: 10.2147/opth.s1629.

Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages.

Revelli S, Le Page C, Piaggio E, Wietzerbin J, Bottasso O Clin Exp Immunol. 1999; 118(2):271-7.

PMID: 10540190 PMC: 1905429. DOI: 10.1046/j.1365-2249.1999.01053.x.

The endogenous balance of soluble tumor necrosis factor receptors and tumor necrosis factor modulates cachexia and mortality in mice acutely infected with Trypanosoma cruzi.

Truyens C, Torrico F, Lucas R, De Baetselier P, Buurman W, Carlier Y Infect Immun. 1999; 67(11):5579-86.

PMID: 10531203 PMC: 96929. DOI: 10.1128/IAI.67.11.5579-5586.1999.

References

Taverne J, Depledge P, Playfair J . Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor. Infect Immun. 1982; 37(3):927-34. PMC: 347627. DOI: 10.1128/iai.37.3.927-934.1982. View

Hauser Jr W, Sharma S, Remington J . Natural killer cells induced by acute and chronic toxoplasma infection. Cell Immunol. 1982; 69(2):330-46. DOI: 10.1016/0008-8749(82)90076-4. View

Kanbara H, Nakabayashi T . Comparative studies on trypomastigotes of Trypanosoma cruzi from infected mouse blood and infected fibroblast cell (L-cell) culture. Biken J. 1983; 26(1):57-62. View

Beutler B, Greenwald D, Hulmes J, Chang M, Pan Y, Mathison J . Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature. 1985; 316(6028):552-4. DOI: 10.1038/316552a0. View

Beutler B, Milsark I, Cerami A . Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol. 1985; 135(6):3972-7. View

De Titto E, Catterall J, Remington J . Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi. J Immunol. 1986; 137(4):1342-5. View

Kirstein M, Fiers W, Baglioni C . Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by high cell density and inhibition of mRNA synthesis. J Immunol. 1986; 137(7):2277-80. View

Tracey K, Beutler B, Lowry S, Merryweather J, Wolpe S, Milsark I . Shock and tissue injury induced by recombinant human cachectin. Science. 1986; 234(4775):470-4. DOI: 10.1126/science.3764421. View

Jones T, Alkan S, Erb P . Spleen and lymph node cell populations, in vitro cell proliferation and interferon-gamma production during the primary immune response to Toxoplasma gondii. Parasite Immunol. 1986; 8(6):619-29. DOI: 10.1111/j.1365-3024.1986.tb00875.x. View

10.

Clark I, Cowden W, Butcher G, Hunt N . Possible roles of tumor necrosis factor in the pathology of malaria. Am J Pathol. 1987; 129(1):192-9. PMC: 1899696. View

11.

Tracey K, Fong Y, Hesse D, Manogue K, Lee A, Kuo G . Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987; 330(6149):662-4. DOI: 10.1038/330662a0. View

12.

Kramer S, Aggarwal B, Eessalu T, McCabe S, Ferraiolo B, Figari I . Characterization of the in vitro and in vivo species preference of human and murine tumor necrosis factor-alpha. Cancer Res. 1988; 48(4):920-5. View

13.

Rothstein J, Schreiber H . Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci U S A. 1988; 85(2):607-11. PMC: 279600. DOI: 10.1073/pnas.85.2.607. View

14.

Tracey K, Lowry S, Cerami A . Cachectin: a hormone that triggers acute shock and chronic cachexia. J Infect Dis. 1988; 157(3):413-20. DOI: 10.1093/infdis/157.3.413. View

15.

Blanchard D, Djeu J, Klein T, Friedman H, Stewart 2nd W . Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function. J Leukoc Biol. 1988; 43(5):429-35. DOI: 10.1002/jlb.43.5.429. View

16.

Brener Z . Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. Rev Inst Med Trop Sao Paulo. 1962; 4:389-96. View

17.

Wilson C, Tsai V, Remington J . Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens. J Exp Med. 1980; 151(2):328-46. PMC: 2185778. DOI: 10.1084/jem.151.2.328. View

18.

Matthews N, Ryley H, Neale M . Tumour-necrosis factor from the rabbit. IV. Purification and chemical characterization. Br J Cancer. 1980; 42(3):416-22. PMC: 2010414. DOI: 10.1038/bjc.1980.253. View

19.

Rouzer C, Cerami A . Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: role of defective triglyceride removal. Mol Biochem Parasitol. 1980; 2(1):31-8. DOI: 10.1016/0166-6851(80)90046-8. View

20.

Parant M . Antimicrobial resistance enhancing activity of tumor necrosis serum factor induced by endotoxin in BCG-treated mice. Recent Results Cancer Res. 1980; 75:213-9. DOI: 10.1007/978-3-642-81491-4_33. View