Neuromyelitis Optica Spectrum Disorders Without and with Autoimmune Diseases

Overview

Journal BMC Neurol

Publisher Biomed Central

Specialty Neurology

Date 2014 Aug 20

PMID 25135481

Citations 15

Authors

Bingjun Zhang

Yi Zhong

Yanqiang Wang

Yongqiang Dai

Wei Qiu

Lei Zhang

Haiyan Li

Zhengqi Lu

Affiliations

Soon will be listed here.

Abstract

Background: Neuromyelitis optica spectrum disorder (NMOSD) can coexist with non-organ-specific or organ-specific autoimmune diseases. The aim of this study was to investigate and compare the features between NMOSD without and with autoimmune diseases, and NMOSD with non-organ-specific and organ-specific autoimmune diseases.

Methods: One hundred and fifty five NMOSD patients without autoimmune diseases (n = 115) and with autoimmune diseases (n = 40) were enrolled. NMOSD with autoimmune diseases were divided by organ-specific autoimmune diseases. The clinical, laboratory and magnetic resonance imaging features between two groups were assessed.

Results: Motor deficit was less frequent in NMOSD patients with non-organ-specific autoimmune diseases (p = 0.024). Cerebrospinal fluid white blood cell and protein, serum C-reactive protein and immunoglobulin G were lower in NMOSD patients without autoimmune diseases, while several autoantibodies seropositivity and thyroid indexes were significantly higher in NMOSD patients with autoimmune diseases (p < 0.05). No difference was found in other clinical and laboratory characteristics between different NMOSD subtypes (p > 0.05). NMOSD patients with autoimmune diseases had higher brain abnormalities than NMOSD without autoimmune diseases (p < 0.001).

Conclusions: The characteristics between NMOSD without and with autoimmune diseases were similar. NMOSD with autoimmune diseases have high frequency of brain abnormalities.

Citing Articles

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Zeng Y, Bai R, Zhou Y, Ren L BMC Neurol. 2022; 22(1):377.

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Yao Y, Yang X, Zhou Y, Xie H, Duan R, Jing L Front Neurol. 2022; 13:969762.

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Neuromyelitis optica spectrum disorder post-COVID-19 infection: A rare case report from Northeast India.

Das D, Bhattacharjee H, Rehman O, Deori N, Magdalene D, Bharali G Indian J Ophthalmol. 2022; 70(5):1833-1836.

PMID: 35502088 PMC: 9333022. DOI: 10.4103/ijo.IJO_61_22.

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