Coping and Glucocorticoid Receptor Regulation by Stress Inoculation

Overview

Journal Psychoneuroendocrinology

Specialties Endocrinology
Neurology
Psychiatry

Date 2014 Aug 16

PMID 25127085

Citations 12

Authors

Alex G Lee

Christine L Buckmaster

Esther Yi

Alan F Schatzberg

David M Lyons

Affiliations

Soon will be listed here.

Abstract

Intermittent exposure to mildly stressful situations provides opportunities to practice coping in the context of exposure psychotherapies and stress inoculation training. Previously, we showed that stress inoculation modeled in juvenile monkeys enhances subsequent indications of resilience. Here we examine stress inoculation effects in adult female monkeys. We found that stress inoculation prevents social separation stress induced anhedonia measured using sucrose preference tests and reduces the hypothalamic pituitary adrenal (HPA) axis stress hormone response to a novel environment. Stress inoculation also increases glucocorticoid receptor (NR3C1) gene expression in anterior cingulate cortex but not hippocampus. Increased anterior cingulate cortex NR3C1 expression induced by stress inoculation is not associated with significant changes in GR1F promoter DNA methylation. On average, low levels of promoter DNA methylation and limited GR1F expression were evident in monkey anterior cingulate cortex as observed in corticolimbic brain regions of adult humans. Taken together these findings suggest that stress inoculation in adulthood enhances behavioral and hormonal aspects of coping without significantly influencing GR1F promoter DNA methylation as a mechanism for NR3C1 transcription regulation.

Citing Articles

Preclinical Models of Chronic Stress: Adaptation or Pathology?.

Radley J, Herman J Biol Psychiatry. 2023; 94(3):194-202.

PMID: 36631383 PMC: 10166771. DOI: 10.1016/j.biopsych.2022.11.004.

Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health.

Shields A, Zhang Y, Argentieri M, Warner E, Cozier Y, Liu C Epigenomics. 2021; 13(21):1711-1734.

PMID: 34726080 PMC: 8579940. DOI: 10.2217/epi-2021-0275.

The Role of Self-Talk in Predicting Death Anxiety, Obsessive-Compulsive Disorder, and Coping Strategies in the Face of Coronavirus Disease (COVID-19).

Sadri Damirchi E, Mojarrad A, Pireinaladin S, Grjibovski A Iran J Psychiatry. 2020; 15(3):182-188.

PMID: 33193766 PMC: 7603592. DOI: 10.18502/ijps.v15i3.3810.

Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice.

Qin X, He Y, Wang N, Zou J, Zhang Y, Cao J Mol Brain. 2019; 12(1):111.

PMID: 31849343 PMC: 6918580. DOI: 10.1186/s13041-019-0534-4.

Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.

Williams S, Ghosh C Drug Discov Today. 2019; 25(1):89-106.

PMID: 31541713 PMC: 6980291. DOI: 10.1016/j.drudis.2019.09.009.

References

Labonte B, Yerko V, Gross J, Mechawar N, Meaney M, Szyf M . Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry. 2012; 72(1):41-8. DOI: 10.1016/j.biopsych.2012.01.034. View

McNally R . Mechanisms of exposure therapy: how neuroscience can improve psychological treatments for anxiety disorders. Clin Psychol Rev. 2007; 27(6):750-9. DOI: 10.1016/j.cpr.2007.01.003. View

Young E . Sex differences in response to exogenous corticosterone: a rat model of hypercortisolemia. Mol Psychiatry. 1996; 1(4):313-9. View

McQuade R, Young A . Future therapeutic targets in mood disorders: the glucocorticoid receptor. Br J Psychiatry. 2000; 177:390-5. DOI: 10.1192/bjp.177.5.390. View

Pandey G, Rizavi H, Ren X, Dwivedi Y, Palkovits M . Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims. Psychoneuroendocrinology. 2013; 38(11):2628-39. PMC: 3812306. DOI: 10.1016/j.psyneuen.2013.06.020. View

Seckl J, Fink G . Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology. 1992; 55(6):621-6. DOI: 10.1159/000126180. View

Patel P, Katz M, Karssen A, Lyons D . Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex. Psychoneuroendocrinology. 2008; 33(3):360-7. PMC: 2386086. DOI: 10.1016/j.psyneuen.2007.12.003. View

Saunders T, Driskell J, Johnston J, Salas E . The effect of stress inoculation training on anxiety and performance. J Occup Health Psychol. 1996; 1(2):170-86. DOI: 10.1037//1076-8998.1.2.170. View

Hebda-Bauer E, Pletsch A, Darwish H, Fentress H, Simmons T, Wei Q . Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit. Neuroscience. 2010; 169(2):645-53. PMC: 2910594. DOI: 10.1016/j.neuroscience.2010.05.033. View

10.

Craske M, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A . Optimizing inhibitory learning during exposure therapy. Behav Res Ther. 2007; 46(1):5-27. DOI: 10.1016/j.brat.2007.10.003. View

11.

Lyons D, Wang O, Lindley S, Levine S, Kalin N, Schatzberg A . Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans. Psychoneuroendocrinology. 1999; 24(2):131-42. DOI: 10.1016/s0306-4530(98)00065-1. View

12.

McGowan P, Sasaki A, DAlessio A, Dymov S, Labonte B, Szyf M . Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009; 12(3):342-8. PMC: 2944040. DOI: 10.1038/nn.2270. View

13.

Katz M, Liu C, Schaer M, Parker K, Ottet M, Epps A . Prefrontal plasticity and stress inoculation-induced resilience. Dev Neurosci. 2009; 31(4):293-9. PMC: 2820579. DOI: 10.1159/000216540. View

14.

Charmandari E, Chrousos G, Lambrou G, Pavlaki A, Koide H, Ng S . Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One. 2011; 6(9):e25612. PMC: 3182238. DOI: 10.1371/journal.pone.0025612. View

15.

Lyons D, Parker K, Schatzberg A . Animal models of early life stress: implications for understanding resilience. Dev Psychobiol. 2010; 52(7):616-24. PMC: 6716163. DOI: 10.1002/dev.20500. View

16.

Peiffer A, Veilleux S, Barden N . Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology. 1991; 16(6):505-15. DOI: 10.1016/0306-4530(91)90034-q. View

17.

Kessler R . Epidemiology of women and depression. J Affect Disord. 2003; 74(1):5-13. DOI: 10.1016/s0165-0327(02)00426-3. View

18.

Stetz M, Thomas M, Russo M, Stetz T, Wildzunas R, McDonald J . Stress, mental health, and cognition: a brief review of relationships and countermeasures. Aviat Space Environ Med. 2007; 78(5 Suppl):B252-60. View

19.

Caudal D, Jay T, Godsil B . Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels. Front Behav Neurosci. 2014; 8:19. PMC: 3905199. DOI: 10.3389/fnbeh.2014.00019. View

20.

Anacker C, Zunszain P, Cattaneo A, Carvalho L, Garabedian M, Thuret S . Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011; 16(7):738-50. PMC: 3121947. DOI: 10.1038/mp.2011.26. View