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Animal Models of Early Life Stress: Implications for Understanding Resilience

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Journal Dev Psychobiol
Date 2010 Oct 20
PMID 20957724
Citations 51
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Abstract

In the mid-1950s, Levine and his colleagues reported that brief intermittent exposure to early life stress diminished indications of subsequent emotionality in rats. Here we review ongoing studies of a similar process in squirrel monkeys. Results from these animal models suggest that brief intermittent exposure to stress promotes the development of arousal regulation and resilience. Implications for programs designed to enhance resilience in human development are discussed.

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References
1.
Levine S, Mody T . The long-term psychobiological consequences of intermittent postnatal separation in the squirrel monkey. Neurosci Biobehav Rev. 2003; 27(1-2):83-9. DOI: 10.1016/s0149-7634(03)00011-3. View

2.
Hofer M . Multiple regulators of ultrasonic vocalization in the infant rat. Psychoneuroendocrinology. 1996; 21(2):203-17. DOI: 10.1016/0306-4530(95)00042-9. View

3.
Fields R . White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 2008; 31(7):361-70. PMC: 2486416. DOI: 10.1016/j.tins.2008.04.001. View

4.
Lyons D, Lopez J, Yang C, Schatzberg A . Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys. J Neurosci. 2000; 20(20):7816-21. PMC: 6772868. View

5.
Lyons D, Martel F, Levine S, Risch N, Schatzberg A . Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress. Horm Behav. 1999; 36(3):266-75. DOI: 10.1006/hbeh.1999.1547. View