Infection Promotes the Invasion and Metastasis of Gastric Cancer Through Increasing the Expression of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-10

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2014 Aug 15

PMID 25120597

Citations 8

Authors

Hao Jiang

Yujuan Zhou

Qianjin Liao

HongJuan OuYang

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the effect and mechanism of infection in the invasion and metastasis of gastric cancer. Specimens from 80 patients with gastric cancer (of which 20 patients had metastatic gastric cancer) and 40 patients with chronic gastritis were included in this study. infection was determined by ELISA and the expression of matrix metalloproteinase-1 (MMP-1) and MMP-10 was observed using immunohistochemistry. The correlation between infection and the clinical pathological features of gastric cancer was analyzed by SPSS 13.0 software. The protein expression levels of MMP-1 and MMP-10 in MGC-803 cells infected with were analyzed using western blotting. infection was found in 62 of the 80 patients with gastric cancer and in 13 of the 40 patients with chronic gastritis. In addition, infection was correlated with the staging and lymph node metastasis, but not with the gender, age and histological types of patients. infection was also significantly correlated with the expression of MMP-1 and MMP-10 (r=0.8718, P<0.05 and r=0.5477, P<0.05, respectively). The expression of MMP-1 and MMP-10 was significantly upregulated following induction by infection (P<0.05), with significant effects occurring following infection for 12 and 6 h, respectively. infection may promote the invasion and metastasis of gastric cancer by increasing the expression of MMP-1 and MMP-10.

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