Status of Epstein-Barr Virus Coinfection with in Gastric Cancer

Overview

Journal J Oncol

Specialty Oncology

Date 2017 Apr 20

PMID 28421114

Citations 32

Authors

Shyam Singh

Hem Chandra Jha

Affiliations

Soon will be listed here.

Abstract

Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, and EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV and , still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV and coinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC.

Citing Articles

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