The TrmB Family: a Versatile Group of Transcriptional Regulators in Archaea

Overview

Journal Extremophiles

Publisher Springer

Date 2014 Aug 14

PMID 25116054

Citations 16

Authors

Antonia Gindner

Winfried Hausner

Michael Thomm

Affiliations

Soon will be listed here.

Abstract

Microbes are organisms which are well adapted to their habitat. Their survival depends on the regulation of gene expression levels in response to environmental signals. The most important step in regulation of gene expression takes place at the transcriptional level. This regulation is intriguing in Archaea because the eu-karyotic-like transcription apparatus is modulated by bacterial-like transcription regulators. The transcriptional regulator of mal operon (TrmB) family is well known as a very large group of regulators in Archaea with more than 250 members to date. One special feature of these regulators is that some of them can act as repressor, some as activator and others as both repressor and activator. This review gives a short updated overview of the TrmB family and their regulatory patterns in different Archaea as a lot of new data have been published on this topic since the last review from 2008.

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