Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Aug 13

PMID 25114912

Citations 14

Authors

Christos Rammos

Ulrike B Hendgen-Cotta

Julia Pohl

Matthias Totzeck

Peter Luedike

Volker T Schulze

Malte Kelm

Tienush Rassaf

Affiliations

Soon will be listed here.

Abstract

Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions.

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References

Rammos C, Hendgen-Cotta U, Sobierajski J, Adamczyk S, Hetzel G, Kleophas W . Macrophage migration inhibitory factor is associated with vascular dysfunction in patients with end-stage renal disease. Int J Cardiol. 2013; 168(6):5249-56. DOI: 10.1016/j.ijcard.2013.08.021. View

Lundberg J, Weitzberg E, Gladwin M . The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008; 7(2):156-67. DOI: 10.1038/nrd2466. View

Roman M, Devereux R, Schwartz J, Lockshin M, Paget S, Davis A . Arterial stiffness in chronic inflammatory diseases. Hypertension. 2005; 46(1):194-9. DOI: 10.1161/01.HYP.0000168055.89955.db. View

Pirro M, Schillaci G, Savarese G, Gemelli F, Mannarino M, Siepi D . Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia. Eur J Cardiovasc Prev Rehabil. 2004; 11(6):497-502. DOI: 10.1097/01.hjr.0000152243.51327.2a. View

Jeffery I, OToole P . Diet-microbiota interactions and their implications for healthy living. Nutrients. 2013; 5(1):234-52. PMC: 3571646. DOI: 10.3390/nu5010234. View

Harper J, Wilkinson J, Miller R . Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction. FASEB J. 2010; 24(7):2436-42. PMC: 2887269. DOI: 10.1096/fj.09-152223. View

Bernhagen J, Krohn R, Lue H, Gregory J, Zernecke A, Koenen R . MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007; 13(5):587-96. DOI: 10.1038/nm1567. View

Mceniery C, Yasmin , Hall I, Qasem A, Wilkinson I, Cockcroft J . Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005; 46(9):1753-60. DOI: 10.1016/j.jacc.2005.07.037. View

Ridker P, Stampfer M, Rifai N . Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA. 2001; 285(19):2481-5. DOI: 10.1001/jama.285.19.2481. View

10.

Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F . Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2006; 128(1):92-105. DOI: 10.1016/j.mad.2006.11.016. View

11.

Pauca A, ORourke M, Kon N . Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension. 2001; 38(4):932-7. DOI: 10.1161/hy1001.096106. View

12.

Santoro A, Pini E, Scurti M, Palmas G, Berendsen A, Brzozowska A . Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design. Mech Ageing Dev. 2013; 136-137:3-13. DOI: 10.1016/j.mad.2013.12.001. View

13.

Yeboah J, Crouse J, Hsu F, Burke G, Herrington D . Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation. 2007; 115(18):2390-7. DOI: 10.1161/CIRCULATIONAHA.106.678276. View

14.

Ridker P, Cushman M, Stampfer M, Tracy R, Hennekens C . Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336(14):973-9. DOI: 10.1056/NEJM199704033361401. View

15.

Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M . Induction of MIF expression by oxidized LDL via activation of NF-kappaB in vascular smooth muscle cells. Atherosclerosis. 2009; 207(2):428-33. DOI: 10.1016/j.atherosclerosis.2009.05.021. View

16.

Schober A, Bernhagen J, Weber C . Chemokine-like functions of MIF in atherosclerosis. J Mol Med (Berl). 2008; 86(7):761-70. DOI: 10.1007/s00109-008-0334-2. View

17.

Sell H, Habich C, Eckel J . Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 2012; 8(12):709-16. DOI: 10.1038/nrendo.2012.114. View

18.

Asare Y, Schmitt M, Bernhagen J . The vascular biology of macrophage migration inhibitory factor (MIF). Expression and effects in inflammation, atherogenesis and angiogenesis. Thromb Haemost. 2013; 109(3):391-8. DOI: 10.1160/TH12-11-0831. View

19.

Sofi F, Cesari F, Abbate R, Gensini G, Casini A . Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008; 337:a1344. PMC: 2533524. DOI: 10.1136/bmj.a1344. View

20.

Baylis D, Bartlett D, Patel H, Roberts H . Understanding how we age: insights into inflammaging. Longev Healthspan. 2014; 2(1):8. PMC: 3922951. DOI: 10.1186/2046-2395-2-8. View