Environmentally Induced Epigenetic Transgenerational Inheritance of Male Infertility

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2014 Aug 9

PMID 25104619

Citations 28

Authors

Carlos Guerrero-Bosagna

Michael K Skinner

Affiliations

Soon will be listed here.

Abstract

Decreasing male fertility has been observed for the past fifty years. Examples of affected reproductive parameters include decreases in sperm count and sperm quality and increases in testicular cancer, cryptorchidism and hypospadias. Exposures to environmental toxicants during fetal development and early postnatal life have been shown to promote infertility. Environmental exposures inducing epigenetic changes related to male infertility range from life style, occupational exposures, environmental toxicants and nutrition. Exposures during fetal gonadal sex determination have been shown to alter the epigenetic programming of the germline that then can transmit this altered epigenetic information to subsequent generations in the absence of any exposures. This environmentally induced epigenetic transgenerational inheritance of disease will be a component of the etiology of male infertility.

Citing Articles

Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.

Haimbaugh A, Meyer D, Connell M, Blount-Pacheco J, Tolofari D, Gonzalez G Int J Environ Res Public Health. 2025; 21(12.

PMID: 39767456 PMC: 11675763. DOI: 10.3390/ijerph21121615.

Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies.

Saftic Martinovic L, Mladenic T, Lovric D, Ostojic S, Devic Pavlic S Epigenomes. 2024; 8(3).

PMID: 39311136 PMC: 11417785. DOI: 10.3390/epigenomes8030034.

Irradiation and Alterations in Hippocampal DNA Methylation.

Impey S, Raber J Epigenomes. 2024; 8(3).

PMID: 39051185 PMC: 11270359. DOI: 10.3390/epigenomes8030027.

Etiology of Male Infertility: an Update.

Bhattacharya I, Sharma S, Majumdar S Reprod Sci. 2023; 31(4):942-965.

PMID: 38036863 DOI: 10.1007/s43032-023-01401-x.

Male infertility.

Eisenberg M, Esteves S, Lamb D, Hotaling J, Giwercman A, Hwang K Nat Rev Dis Primers. 2023; 9(1):49.

PMID: 37709866 DOI: 10.1038/s41572-023-00459-w.

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