Pancreatic Islet-specific T-cell Clones from Nonobese Diabetic Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1989 Oct 1

PMID 2510155

Citations 88

Authors

K Haskins

M Portas

B Bergman

K Lafferty

B Bradley

Affiliations

Soon will be listed here.

Abstract

We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.

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