Pregnancy-secreted Acid Phosphatase, Uteroferrin, Enhances Fetal Erythropoiesis

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2014 Aug 6

PMID 25093463

Citations 4

Authors

Wei Ying

Haiqing Wang

Fuller W Bazer

Beiyan Zhou

Affiliations

Soon will be listed here.

Abstract

Uteroferrin (UF) is a progesterone-induced acid phosphatase produced by uterine glandular epithelia in mammals during pregnancy and targeted to sites of hematopoiesis throughout pregnancy. The expression pattern of UF is coordinated with early fetal hematopoietic development in the yolk sac and then liver, spleen, and bone to prevent anemia in fetuses. Our previous studies suggested that UF exerts stimulatory impacts on hematopoietic progenitor cells. However, the precise role and thereby the mechanism of action of UF on hematopoiesis have not been investigated previously. Here, we report that UF is a potent regulator that can greatly enhance fetal erythropoiesis. Using primary fetal liver hematopoietic cells, we observed a synergistic stimulatory effect of UF with erythropoietin and other growth factors on both burst-forming unit-erythroid and colony-forming unit-erythroid formation. Further, we demonstrated that UF enhanced erythropoiesis at terminal stages using an in vitro culture system. Surveying genes that are crucial for erythrocyte formation at various stages revealed that UF, along with erythropoietin, up-regulated transcription factors required for terminal erythrocyte differentiation and genes required for synthesis of hemoglobin. Collectively, our results demonstrate that UF is a cytokine secreted by uterine glands in response to progesterone that promotes fetal erythropoiesis at various stages of pregnancy, including burst-forming unit-erythroid and colony-forming unit-erythroid progenitor cells and terminal stages of differentiation of hematopoietic cells in the erythroid lineage.

Citing Articles

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Stenhouse C, Seo H, Wu G, Johnson G, Bazer F Adv Exp Med Biol. 2021; 1354:25-48.

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Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells.

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Pulse of inflammatory proteins in the pregnant uterus of European polecats () leading to the time of implantation.

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