New Molecular Targets and Lifestyle Interventions to Delay Aging Sarcopenia

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2014 Jul 30

PMID 25071565

Citations 11

Authors

Fabian Sanchis-Gomar

Helios Pareja-Galeano

Sara Mayero

Carme Perez-Quilis

Alejandro Lucia

Affiliations

Soon will be listed here.

Citing Articles

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis.

Wang J, Jia D, Zhang Z, Wang D Metabolites. 2025; 15(1).

PMID: 39852400 PMC: 11767263. DOI: 10.3390/metabo15010059.

Effects of nonalcoholic fatty liver disease on sarcopenia: evidence from genetic methods.

Yuan J, Zhang J, Luo Q, Peng L Sci Rep. 2024; 14(1):2709.

PMID: 38302636 PMC: 10834579. DOI: 10.1038/s41598-024-53112-1.

Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors.

Pahlavani H Front Endocrinol (Lausanne). 2022; 13:811751.

PMID: 35250869 PMC: 8892203. DOI: 10.3389/fendo.2022.811751.

Sarcopenia in aging, obesity, and cancer.

Ligibel J, Schmitz K, Berger N Transl Cancer Res. 2020; 9(9):5760-5771.

PMID: 33163373 PMC: 7643855. DOI: 10.21037/tcr-2019-eaoc-05.

Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion.

Sanchis-Gomar F, Lopez-Lopez S, Romero-Morales C, Maffulli N, Lippi G, Pareja-Galeano H Front Physiol. 2019; 10:1463.

PMID: 31849710 PMC: 6894042. DOI: 10.3389/fphys.2019.01463.

References

Garatachea N, Pinos T, Camara Y, Rodriguez-Romo G, Emanuele E, Ricevuti G . Association of the K153R polymorphism in the myostatin gene and extreme longevity. Age (Dordr). 2013; 35(6):2445-54. PMC: 3825013. DOI: 10.1007/s11357-013-9513-3. View

Morley J, Abbatecola A, Argiles J, Baracos V, Bauer J, Bhasin S . Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc. 2011; 12(6):403-9. PMC: 5100674. DOI: 10.1016/j.jamda.2011.04.014. View

Marzetti E, Lawler J, Hiona A, Manini T, Seo A, Leeuwenburgh C . Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radic Biol Med. 2008; 44(2):160-8. DOI: 10.1016/j.freeradbiomed.2007.05.028. View

Sanchis-Gomar F, Gomez-Cabrera M, Vina J . The loss of muscle mass and sarcopenia: non hormonal intervention. Exp Gerontol. 2011; 46(12):967-9. DOI: 10.1016/j.exger.2011.08.012. View

Song Z, von Figura G, Liu Y, Kraus J, Torrice C, Dillon P . Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell. 2010; 9(4):607-15. PMC: 2910221. DOI: 10.1111/j.1474-9726.2010.00583.x. View

Sanchis-Gomar F, Pareja-Galeano H, Lucia A . The hMTH1 paradox: antioxidants recommended in cancer?. DNA Repair (Amst). 2014; 21:163-4. DOI: 10.1016/j.dnarep.2014.04.010. View

Fiatarone M, Marks E, Ryan N, Meredith C, Lipsitz L, Evans W . High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA. 1990; 263(22):3029-34. View

Derbre F, Gomez-Cabrera M, Nascimento A, Sanchis-Gomar F, Martinez-Bello V, Tresguerres J . Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training. Age (Dordr). 2011; 34(3):669-79. PMC: 3337936. DOI: 10.1007/s11357-011-9264-y. View

Gomes A, Price N, Ling A, Moslehi J, Montgomery M, Rajman L . Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013; 155(7):1624-38. PMC: 4076149. DOI: 10.1016/j.cell.2013.11.037. View

10.

Kim K, Kim S, Min Y, Yang H, Lee J, Lee M . Acute exercise induces FGF21 expression in mice and in healthy humans. PLoS One. 2013; 8(5):e63517. PMC: 3646740. DOI: 10.1371/journal.pone.0063517. View

11.

Gladyshev V . The free radical theory of aging is dead. Long live the damage theory!. Antioxid Redox Signal. 2013; 20(4):727-31. PMC: 3901353. DOI: 10.1089/ars.2013.5228. View

12.

Sandri M, Barberi L, Bijlsma A, Blaauw B, Dyar K, Milan G . Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology. 2013; 14(3):303-23. DOI: 10.1007/s10522-013-9432-9. View

13.

Lee J, Budanov A, Karin M . Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013; 18(6):792-801. PMC: 3858445. DOI: 10.1016/j.cmet.2013.08.018. View

14.

Sanchis-Gomar F . The skeletal muscle-metabolism axis in prostate-cancer therapy. N Engl J Med. 2012; 367(23):2257-8. DOI: 10.1056/NEJMc1211955. View

15.

Liu C, Latham N . Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev. 2009; (3):CD002759. PMC: 4324332. DOI: 10.1002/14651858.CD002759.pub2. View

16.

Tsygankov D, Liu Y, Sanoff H, Sharpless N, Elston T . A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. Proc Natl Acad Sci U S A. 2009; 106(39):16562-7. PMC: 2757807. DOI: 10.1073/pnas.0904405106. View

17.

Bostrom P, Wu J, Jedrychowski M, Korde A, Ye L, Lo J . A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012; 481(7382):463-8. PMC: 3522098. DOI: 10.1038/nature10777. View

18.

Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M . Autophagy is required to maintain muscle mass. Cell Metab. 2009; 10(6):507-15. DOI: 10.1016/j.cmet.2009.10.008. View

19.

Fiuza-Luces C, Garatachea N, Berger N, Lucia A . Exercise is the real polypill. Physiology (Bethesda). 2013; 28(5):330-58. DOI: 10.1152/physiol.00019.2013. View

20.

Argiles J, Anker S, Evans W, Morley J, Fearon K, Strasser F . Consensus on cachexia definitions. J Am Med Dir Assoc. 2010; 11(4):229-30. DOI: 10.1016/j.jamda.2010.02.004. View