Cardiovascular Disorders in Anorexia Nervosa and Potential Therapeutic Targets

Overview

Journal Intern Emerg Med

Publisher Springer

Specialties Emergency Medicine
General Medicine

Date 2014 Jul 25

PMID 25056404

Citations 5

Authors

Giovanni Di Cola

Francesca Jacoangeli

Fabrizio Jacoangeli

Mauro Lombardo

Ferdinando Iellamo

Affiliations

Soon will be listed here.

Abstract

Anorexia nervosa (AN) is an eating disorder in which a distorted self-perception of body image and an excessive fear of gaining weight result in extreme restrictions in eating habits. AN may be divided into two types: a "binge-eating/purging type" during which the individual regularly engages in overeating and then purging behavior, and a "restricting type", in which she does not. AN is a serious medical problem in young people in Western societies. It is widely reported that patients with AN exhibit an enhanced mortality rate as compared with age-matched healthy subjects, which has been mainly ascribed to cardiac complications. At least one-third of all deaths in patients with anorexia nervosa are estimated to be due to cardiac causes, mainly sudden death. Cardiovascular complications of AN can be present in up to 80% of cases, and among them alterations in cardiac electrical activity, structure and hemodynamics have been reported as causes of morbidity and mortality. The objective of this brief review is to summarize current knowledge on the main cardiovascular complications of AN, their underlying mechanisms and the possible therapeutic approaches.

Citing Articles

Shared genetic risk between anorexia nervosa and cardiovascular disease events: Evidence from genome-wide association studies.

Qi B, Graff M, Eating Disorders Working Group Of The Psychiatric Genomics Consortium , Bulik C, North K, Munn-Chernoff M Brain Behav. 2024; 14(2):e3294.

PMID: 38282367 PMC: 10897497. DOI: 10.1002/brb3.3294.

Myocardial mechanics and cardiac biomarkers in adults with severe anorexia nervosa.

Krantz M, Watters A, Oakes J, Frazier M, Mehler P J Echocardiogr. 2023; 22(2):79-87.

PMID: 37989977 DOI: 10.1007/s12574-023-00629-5.

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results.

Brinkmann F, Hanusch B, Ballmann M, Mayorandan S, Bollenbach A, Chobanyan-Jurgens K J Clin Med. 2020; 9(6).

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Heart and anorexia nervosa.

Fayssoil A, Melchior J, Hanachi M Heart Fail Rev. 2019; 26(1):65-70.

PMID: 31873842 DOI: 10.1007/s10741-019-09911-0.

Markers of Cardiovascular Dysfunction in Adolescents With Anorexia Nervosa.

Morris R, Prasad A, Asaro J, Guzman M, Sanders L, Hauck A Glob Pediatr Health. 2017; 4:2333794X17727423.

PMID: 28890913 PMC: 5580842. DOI: 10.1177/2333794X17727423.

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