Coaxing Stem Cells for Skeletal Muscle Repair

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2014 Jul 23

PMID 25049085

Citations 23

Authors

Karl J A McCullagh

Rita C R Perlingeiro

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle has a tremendous ability to regenerate, attributed to a well-defined population of muscle stem cells called satellite cells. However, this ability to regenerate diminishes with age and can also be dramatically affected by multiple types of muscle diseases, or injury. Extrinsic and/or intrinsic defects in the regulation of satellite cells are considered to be major determinants for the diminished regenerative capacity. Maintenance and replenishment of the satellite cell pool is one focus for muscle regenerative medicine, which will be discussed. There are other sources of progenitor cells with myogenic capacity, which may also support skeletal muscle repair. However, all of these myogenic cell populations have inherent difficulties and challenges in maintaining or coaxing their derivation for therapeutic purpose. This review will highlight recent reported attributes of these cells and new bioengineering approaches to creating a supply of myogenic stem cells or implants applicable for acute and/or chronic muscle disorders.

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References

Rinaldi F, Perlingeiro R . Stem cells for skeletal muscle regeneration: therapeutic potential and roadblocks. Transl Res. 2013; 163(4):409-17. PMC: 3976768. DOI: 10.1016/j.trsl.2013.11.006. View

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K . Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861-72. DOI: 10.1016/j.cell.2007.11.019. View

Goudenege S, LeBel C, Huot N, Dufour C, Fujii I, Gekas J . Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation. Mol Ther. 2012; 20(11):2153-67. PMC: 3498803. DOI: 10.1038/mt.2012.188. View

Joe A, Yi L, Natarajan A, Le Grand F, So L, Wang J . Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol. 2010; 12(2):153-63. PMC: 4580288. DOI: 10.1038/ncb2015. View

Carosio S, Barberi L, Rizzuto E, Nicoletti C, Del Prete Z, Musaro A . Generation of eX vivo-vascularized Muscle Engineered Tissue (X-MET). Sci Rep. 2013; 3:1420. PMC: 3594753. DOI: 10.1038/srep01420. View

Filareto A, Darabi R, Perlingeiro R . Engraftment of ES-Derived Myogenic Progenitors in a Severe Mouse Model of Muscular Dystrophy. J Stem Cell Res Ther. 2013; 10(1). PMC: 3593119. DOI: 10.4172/2157-7633.S10-001. View

Dennis R, Kosnik 2nd P . Excitability and isometric contractile properties of mammalian skeletal muscle constructs engineered in vitro. In Vitro Cell Dev Biol Anim. 2000; 36(5):327-35. DOI: 10.1290/1071-2690(2000)036<0327:EAICPO>2.0.CO;2. View

Soderpalm A, Magnusson P, Ahlander A, Karlsson J, Kroksmark A, Tulinius M . Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Neuromuscul Disord. 2007; 17(11-12):919-28. DOI: 10.1016/j.nmd.2007.05.008. View

Gillies A, Lieber R . Structure and function of the skeletal muscle extracellular matrix. Muscle Nerve. 2011; 44(3):318-31. PMC: 3177172. DOI: 10.1002/mus.22094. View

10.

Koo T, Popplewell L, Athanasopoulos T, Dickson G . Triple trans-splicing adeno-associated virus vectors capable of transferring the coding sequence for full-length dystrophin protein into dystrophic mice. Hum Gene Ther. 2013; 25(2):98-108. DOI: 10.1089/hum.2013.164. View

11.

Yin H, Price F, Rudnicki M . Satellite cells and the muscle stem cell niche. Physiol Rev. 2013; 93(1):23-67. PMC: 4073943. DOI: 10.1152/physrev.00043.2011. View

12.

Gopinath S, Webb A, Brunet A, Rando T . FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports. 2014; 2(4):414-26. PMC: 3986584. DOI: 10.1016/j.stemcr.2014.02.002. View

13.

Ousterout D, Perez-Pinera P, Thakore P, Kabadi A, Brown M, Qin X . Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. Mol Ther. 2013; 21(9):1718-26. PMC: 3776627. DOI: 10.1038/mt.2013.111. View

14.

Sampaolesi M, Torrente Y, Innocenzi A, Tonlorenzi R, DAntona G, Pellegrino M . Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science. 2003; 301(5632):487-92. DOI: 10.1126/science.1082254. View

15.

Benchaouir R, Meregalli M, Farini A, DAntona G, Belicchi M, Goyenvalle A . Restoration of human dystrophin following transplantation of exon-skipping-engineered DMD patient stem cells into dystrophic mice. Cell Stem Cell. 2008; 1(6):646-57. DOI: 10.1016/j.stem.2007.09.016. View

16.

Bjornson C, Cheung T, Liu L, Tripathi P, Steeper K, Rando T . Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2011; 30(2):232-42. PMC: 3384696. DOI: 10.1002/stem.773. View

17.

Rossi C, Flaibani M, Blaauw B, Pozzobon M, Figallo E, Reggiani C . In vivo tissue engineering of functional skeletal muscle by freshly isolated satellite cells embedded in a photopolymerizable hydrogel. FASEB J. 2011; 25(7):2296-304. DOI: 10.1096/fj.10-174755. View

18.

Ichim T, Alexandrescu D, Solano F, Lara F, de Necochea Campion R, Paris E . Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy. Cell Immunol. 2009; 260(2):75-82. DOI: 10.1016/j.cellimm.2009.10.006. View

19.

Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P . Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell. 2010; 143(7):1059-71. PMC: 3025608. DOI: 10.1016/j.cell.2010.11.039. View

20.

Hinds S, Bian W, Dennis R, Bursac N . The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials. 2011; 32(14):3575-83. PMC: 3057410. DOI: 10.1016/j.biomaterials.2011.01.062. View