Visual Outcome and Prognostic Factors After Surgery for a Secondary Epiretinal Membrane Associated with Branch Retinal Vein Occlusion

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2014 Jul 21

PMID 25038909

Citations 11

Authors

Hae Min Kang

Hyoung Jun Koh

Sung Chul Lee

Affiliations

Soon will be listed here.

Abstract

Purpose: To assess the visual outcome and prognostic factors after surgery for a secondary epiretinal membrane (ERM) due to branch retinal vein occlusion (BRVO).

Methods: Medical records of 33 patients (33 eyes) were retrospectively reviewed. All patients underwent vitrectomy and completed at least one year of follow-up. Patients characteristics, including baseline best-corrected visual acuity (BCVA; logMAR, logarithm of the minimum angle resolution), fluorescein angiography and optical coherence tomography findings were analyzed.

Results: Twenty eyes (60.6%) were non-ischemic and nine eyes (27.3%) had ischemic maculopathy. The mean BCVA was 0.82 ±0.56 logMAR (20/132 Snellen equivalent) at baseline and 0.43 ±0.37 logMAR (20/53 Snellen equivalent) at 1 year (p = 0.001). At 1 year three eyes (9.1%) had visual loss with 0.3 logMAR or more deterioration than baseline whereas 16 eyes (48.5%) gained vision. The mean central macular thickness (CMT) was 407.3 ±138.8 μm at baseline and 274.71 ±40.5 μm at 1 year after surgery (p = 0.001). Photoreceptor integrity was intact in 20 eyes (60.6%). Photoreceptor integrity (B = 0.248, p = 0.001) at baseline was significantly correlated with visual outcome after surgery.

Conclusion: Surgery for a secondary ERM associated with BRVO led to a relatively favorable visual outcome. The integrity of photoreceptors at baseline seems to be useful in predicting visual outcome in these patients.

Citing Articles

Predictors of macular edema recurrence and visual outcomes in branch retinal vein occlusion treated with aflibercept or ranibizumab.

Chang J, Chien H, Hsieh Y, Liu K, Kuo P, Ho C Int Ophthalmol. 2025; 45(1):96.

PMID: 40085265 DOI: 10.1007/s10792-025-03480-y.

Anatomical, Functional, and Prognostic Results of Vitrectomy in Epiretinal Membranes Secondary to Retinal Vein Occlusions.

Chung Y, Mainguy A, Chatziralli I, Smaoui A, Bodaghi B, Paques M Ophthalmologica. 2024; 248(1):29-39.

PMID: 39586293 PMC: 11901413. DOI: 10.1159/000542770.

Does Laser Iridotomy Cause Secondary Epiretinal Membrane?.

Akmaz O, Talay N Turk J Ophthalmol. 2024; 54(5):263-267.

PMID: 39463150 PMC: 11589235. DOI: 10.4274/tjo.galenos.2024.61094.

Negative impact of internal limiting membrane peeling in vitreous hemorrhage secondary to retinal vein occlusion with macular ischemia.

Shiraki A, Shiraki N, Maruyama K, Wakabayashi T, Sakimoto S, Maeno T Graefes Arch Clin Exp Ophthalmol. 2024; 263(2):369-377.

PMID: 39390122 PMC: 11868332. DOI: 10.1007/s00417-024-06645-0.

Clinical factors and predictors for spontaneous separation of epiretinal membranes.

Lee J, Lee J, Lee C, Kim M, Byeon S, Kim S Graefes Arch Clin Exp Ophthalmol. 2024; 263(2):347-359.

PMID: 39354154 DOI: 10.1007/s00417-024-06646-z.

References

Shilling J, Kohner E . New vessel formation in retinal branch vein occlusion. Br J Ophthalmol. 1976; 60(12):810-5. PMC: 1042850. DOI: 10.1136/bjo.60.12.810. View

Benichou C, Flament J . [Epiretinal membrane and photocoagulation with argon laser. Discussion of 3 cases]. Bull Soc Ophtalmol Fr. 1989; 89(4):613-9. View

Hvarfner C, Andreasson S, Larsson J . Multifocal electroretinography and fluorescein angiography in retinal vein occlusion. Retina. 2006; 26(3):292-6. DOI: 10.1097/00006982-200603000-00007. View

Kim J, Kim Y, Chung E, Lee S, Koh H . Structural and functional predictors of visual outcome of epiretinal membrane surgery. Am J Ophthalmol. 2011; 153(1):103-10.e1. DOI: 10.1016/j.ajo.2011.06.021. View

Klein R, Klein B, Moss S, Meuer S . The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc. 2001; 98:133-41; discussion 141-3. PMC: 1298220. View

Marticorena J, Romano M, Heimann H, Stappler T, Gibran K, Groenewald C . Intravitreal bevacizumab for retinal vein occlusion and early growth of epiretinal membrane: a possible secondary effect?. Br J Ophthalmol. 2010; 95(3):391-5. DOI: 10.1136/bjo.2009.177287. View

Wong T, Scott I . Clinical practice. Retinal-vein occlusion. N Engl J Med. 2010; 363(22):2135-44. DOI: 10.1056/NEJMcp1003934. View

rehak J, Rehak M . Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res. 2008; 33(2):111-31. PMC: 2430176. DOI: 10.1080/02713680701851902. View

Amirikia A, Scott I, Murray T, Flynn Jr H, Smiddy W, Feuer W . Outcomes of vitreoretinal surgery for complications of branch retinal vein occlusion. Ophthalmology. 2001; 108(2):372-6. DOI: 10.1016/s0161-6420(00)00512-1. View

10.

Kang H, Chung E, Kim Y, Koh H . Spectral-domain optical coherence tomography (SD-OCT) patterns and response to intravitreal bevacizumab therapy in macular edema associated with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2012; 251(2):501-8. DOI: 10.1007/s00417-012-2067-8. View

11.

Mitamura Y, Hirano K, Baba T, Yamamoto S . Correlation of visual recovery with presence of photoreceptor inner/outer segment junction in optical coherence images after epiretinal membrane surgery. Br J Ophthalmol. 2008; 93(2):171-5. DOI: 10.1136/bjo.2008.146381. View

12.

Harada C, Mitamura Y, Harada T . The role of cytokines and trophic factors in epiretinal membranes: involvement of signal transduction in glial cells. Prog Retin Eye Res. 2005; 25(2):149-64. DOI: 10.1016/j.preteyeres.2005.09.001. View

13.

Mitchell P, Smith W, Chang A . Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol. 1996; 114(10):1243-7. DOI: 10.1001/archopht.1996.01100140443012. View

14.

Suh M, Seo J, Park K, Yu H . Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal. Am J Ophthalmol. 2008; 147(3):473-480.e3. DOI: 10.1016/j.ajo.2008.09.020. View

15.

Oster S, Mojana F, Brar M, Yuson R, Cheng L, Freeman W . Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina. 2009; 30(5):713-8. DOI: 10.1097/IAE.0b013e3181c596e3. View

16.

Puliafito C, Hee M, Lin C, Reichel E, Schuman J, Duker J . Imaging of macular diseases with optical coherence tomography. Ophthalmology. 1995; 102(2):217-29. DOI: 10.1016/s0161-6420(95)31032-9. View

17.

Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S . Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane. Am J Ophthalmol. 2010; 150(6):834-9. DOI: 10.1016/j.ajo.2010.06.006. View

18.

Takahashi M, Hirokawa H, Trempe C . [Vitreous detachment, neovascularization, and vitreous hemorrhage in retinal branch vein occlusion (author's transl)]. Nippon Ganka Gakkai Zasshi. 1981; 85(7):731-6. View

19.

Hiscott P, Grierson I, McLeod D . Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol. 1985; 69(11):810-23. PMC: 1040751. DOI: 10.1136/bjo.69.11.810. View

20.

Sakimoto S, Saito Y, Nakata K, Sakamoto Y, Tatebayashi M . Surgical outcomes of epiretinal membrane removal after successful pars plana vitrectomy for retinal diseases. Jpn J Ophthalmol. 2008; 52(3):227-230. DOI: 10.1007/s10384-008-0539-5. View