MiR-9 Promotes Microglial Activation by Targeting MCPIP1

Overview

Journal Nat Commun

Specialty Biology

Date 2014 Jul 15

PMID 25019481

Citations 90

Authors

Honghong Yao

Rong Ma

Lu Yang

Guoku Hu

Xufeng Chen

Ming Duan

Yeonhee Kook

Fang Niu

Ke Liao

Minggui Fu

Gang Hu

Pappachan Kolattukudy

Shilpa Buch

Affiliations

Soon will be listed here.

Abstract

Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κB pathway, but not the β-catenin pathway.

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