Alterations of MRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer's Disease

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2024 Jan 18

PMID 38236345

Authors

Karla Aketzalli Hernandez-Contreras

Jorge Antonio Martinez-Diaz

Maria Elena Hernandez-Aguilar

Deissy Herrera-Covarrubias

Fausto Rojas-Duran

Lizbeth Donaji Chi-Castaneda

Luis Isauro Garcia-Hernandez

Gonzalo Emiliano Aranda-Abreu

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease is a neurodegenerative pathology whose pathognomonic hallmarks are increased generation of β-amyloid (Aβ) peptide, production of hyperphosphorylated (pTau), and neuroinflammation. The last is an alteration closely related to the progression of AD and although it is present in multiple neurodegenerative diseases, the pathophysiological events that characterize neuroinflammatory processes vary depending on the disease. In this article, we focus on mRNA and non-coding RNA alterations as part of the pathophysiological events characteristic of neuroinflammation in AD and the influence of these alterations on the course of the disease through interaction with multiple RNAs related to the generation of Aβ, pTau, and neuroinflammation itself.

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