Optical Neural Interfaces

Overview

Journal Annu Rev Biomed Eng

Publisher Annual Reviews

Specialty Biomedical Engineering

Date 2014 Jul 12

PMID 25014785

Citations 71

Authors

Melissa R Warden

Jessica A Cardin

Karl Deisseroth

Affiliations

Soon will be listed here.

Abstract

Genetically encoded optical actuators and indicators have changed the landscape of neuroscience, enabling targetable control and readout of specific components of intact neural circuits in behaving animals. Here, we review the development of optical neural interfaces, focusing on hardware designed for optical control of neural activity, integrated optical control and electrical readout, and optical readout of population and single-cell neural activity in freely moving mammals.

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References

Murayama M, Perez-Garci E, Nevian T, Bock T, Senn W, Larkum M . Dendritic encoding of sensory stimuli controlled by deep cortical interneurons. Nature. 2009; 457(7233):1137-41. DOI: 10.1038/nature07663. View

Ohkura M, Matsuzaki M, Kasai H, Imoto K, Nakai J . Genetically encoded bright Ca2+ probe applicable for dynamic Ca2+ imaging of dendritic spines. Anal Chem. 2005; 77(18):5861-9. DOI: 10.1021/ac0506837. View

Han X, Boyden E . Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One. 2007; 2(3):e299. PMC: 1808431. DOI: 10.1371/journal.pone.0000299. View

Helmchen F, Fee M, Tank D, Denk W . A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animals. Neuron. 2001; 31(6):903-12. DOI: 10.1016/s0896-6273(01)00421-4. View

Aravanis A, Wang L, Zhang F, Meltzer L, Mogri M, Schneider M . An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng. 2007; 4(3):S143-56. DOI: 10.1088/1741-2560/4/3/S02. View

Zariwala H, Borghuis B, Hoogland T, Madisen L, Tian L, De Zeeuw C . A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci. 2012; 32(9):3131-41. PMC: 3315707. DOI: 10.1523/JNEUROSCI.4469-11.2012. View

Laffray S, Pages S, Dufour H, De Koninck P, De Koninck Y, Cote D . Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue. PLoS One. 2011; 6(5):e19928. PMC: 3101223. DOI: 10.1371/journal.pone.0019928. View

Kerr J, Nimmerjahn A . Functional imaging in freely moving animals. Curr Opin Neurobiol. 2012; 22(1):45-53. DOI: 10.1016/j.conb.2011.12.002. View

Stark E, Koos T, Buzsaki G . Diode probes for spatiotemporal optical control of multiple neurons in freely moving animals. J Neurophysiol. 2012; 108(1):349-63. PMC: 3434617. DOI: 10.1152/jn.00153.2012. View

10.

Dombeck D, Khabbaz A, Collman F, Adelman T, Tank D . Imaging large-scale neural activity with cellular resolution in awake, mobile mice. Neuron. 2007; 56(1):43-57. PMC: 2268027. DOI: 10.1016/j.neuron.2007.08.003. View

11.

Paukert M, Bergles D . Reduction of motion artifacts during in vivo two-photon imaging of brain through heartbeat triggered scanning. J Physiol. 2012; 590(13):2955-63. PMC: 3406383. DOI: 10.1113/jphysiol.2012.228114. View

12.

Regehr W, Tank D . Selective fura-2 loading of presynaptic terminals and nerve cell processes by local perfusion in mammalian brain slice. J Neurosci Methods. 1991; 37(2):111-9. DOI: 10.1016/0165-0270(91)90121-f. View

13.

Gradinaru V, Thompson K, Zhang F, Mogri M, Kay K, Schneider M . Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci. 2007; 27(52):14231-8. PMC: 6673457. DOI: 10.1523/JNEUROSCI.3578-07.2007. View

14.

Persechini A, Lynch J, Romoser V . Novel fluorescent indicator proteins for monitoring free intracellular Ca2+. Cell Calcium. 1997; 22(3):209-16. DOI: 10.1016/s0143-4160(97)90014-2. View

15.

Ohkura M, Sasaki T, Kobayashi C, Ikegaya Y, Nakai J . An improved genetically encoded red fluorescent Ca2+ indicator for detecting optically evoked action potentials. PLoS One. 2012; 7(7):e39933. PMC: 3393713. DOI: 10.1371/journal.pone.0039933. View

16.

Iwai Y, Honda S, Ozeki H, Hashimoto M, Hirase H . A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice. Neurosci Res. 2011; 70(1):124-7. DOI: 10.1016/j.neures.2011.01.007. View

17.

Nimmerjahn A, Kirchhoff F, Kerr J, Helmchen F . Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods. 2005; 1(1):31-7. DOI: 10.1038/nmeth706. View

18.

Airan R, Thompson K, Fenno L, Bernstein H, Deisseroth K . Temporally precise in vivo control of intracellular signalling. Nature. 2009; 458(7241):1025-9. DOI: 10.1038/nature07926. View

19.

Constantinidis C, Goldman-Rakic P . Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex. J Neurophysiol. 2002; 88(6):3487-97. DOI: 10.1152/jn.00188.2002. View

20.

Dugue G, Akemann W, Knopfel T . A comprehensive concept of optogenetics. Prog Brain Res. 2012; 196:1-28. DOI: 10.1016/B978-0-444-59426-6.00001-X. View