Prestimulation Phase Predicts the TMS-evoked Response

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2014 Jul 11

PMID 25008413

Citations 16

Authors

Bornali Kundu

Jeffrey S Johnson

Bradley R Postle

Affiliations

Soon will be listed here.

Abstract

Prestimulation oscillatory phase and power in particular frequency bands predict perception of at-threshold visual stimuli and of transcranial magnetic stimulation (TMS)-induced phosphenes. These effects may be due to changes in cortical excitability, such that certain ranges of power and/or phase values result in a state in which a particular brain area is more receptive to input, thereby biasing behavior. However, the effects of trial-by-trial fluctuations in phase and power of ongoing oscillations on the brain's electrical response to TMS itself have thus far not been addressed. The present study adopts a combined TMS and electroencepalography (EEG) approach to determine whether the TMS-evoked response is sensitive to momentary fluctuations in prestimulation phase and/or power in different frequency bands. Specifically, TMS was applied to superior parietal lobule while subjects performed a short-term memory task. Results showed that the prestimulation phase, particularly within the beta (15-25 Hz) band, predicted pulse-by-pulse variations in the global mean field amplitude. No such relationship was observed between prestimulation power and the global mean field amplitude. Furthermore, TMS-evoked power in the beta band fluctuated with prestimulation phase in the beta band in a manner that differed from spontaneous brain activity. These effects were observed in areas at and distal to the stimulation site. Together, these results confirm the idea that fluctuating phase of ongoing neuronal oscillations create "windows of excitability" in the brain, and they give insight into how TMS interacts with ongoing brain activity on a pulse-by-pulse basis.

Citing Articles

Influence of Large-Scale Brain State Dynamics on the Evoked Response to Brain Stimulation.

Kabir A, Dhami P, Dussault Gomez M, Blumberger D, Daskalakis Z, Moreno S J Neurosci. 2024; 44(39).

PMID: 39164105 PMC: 11426374. DOI: 10.1523/JNEUROSCI.0782-24.2024.

Pre-Stimulus Power but Not Phase Predicts Prefrontal Cortical Excitability in TMS-EEG.

Poorganji M, Zomorrodi R, Zrenner C, Bansal A, Hawco C, Hill A Biosensors (Basel). 2023; 13(2).

PMID: 36831986 PMC: 9953459. DOI: 10.3390/bios13020220.

Human hippocampal responses to network intracranial stimulation vary with theta phase.

Lurie S, Kragel J, Schuele S, Voss J Elife. 2022; 11.

PMID: 36453717 PMC: 9733942. DOI: 10.7554/eLife.78395.

Local brain-state dependency of effective connectivity: a pilot TMS-EEG study.

Grano I, Mutanen T, Tervo A, Nieminen J, Souza V, Fecchio M Open Res Eur. 2023; 2:45.

PMID: 36035767 PMC: 7613446. DOI: 10.12688/openreseurope.14634.2.

The Problem and Potential of TMS' Infinite Parameter Space: A Targeted Review and Road Map Forward.

Caulfield K, Brown J Front Psychiatry. 2022; 13:867091.

PMID: 35619619 PMC: 9127062. DOI: 10.3389/fpsyt.2022.867091.

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