Isolation, Structural Analyses and Biological Activity Assays Against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2014 Jul 10

PMID 25006786

Citations 1

Authors

Lene M Petersen

Tanja T Bladt

Claudia Durr

Martina Seiffert

Jens C Frisvad

Charlotte H Gotfredsen

Thomas O Larsen

Affiliations

Soon will be listed here.

Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.

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