Maternal Glomerular Filtration Rate in Pregnancy and Fetal Size

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jul 9

PMID 25003331

Citations 31

Authors

Nils-Halvdan Morken

Gregory S Travlos

Ralph E Wilson

Merete Eggesbo

Matthew P Longnecker

Affiliations

Soon will be listed here.

Abstract

Background: The relationship of maternal glomerular filtration rate (GFR) in pregnancy to fetal size needs to be better characterized as it impacts an ongoing debate about confounding effect of maternal GFR in investigations of important environmental contaminants. We aimed to characterize the size of the association between maternal GFR and infant birth weight.

Materials And Methods: A sub-cohort of 953 selected women (470 women with and 483 women without preeclampsia) in the Norwegian Mother and Child Cohort (MoBa), recruited during 2003-2007 were analyzed. GFR in the second trimester was estimated based on plasma creatinine. Birth weight was ascertained from the Medical Birth Registry of Norway. Multivariate linear regression was used to evaluate the association between maternal GFR in second trimester (estimated by the Cockroft-Gault [GFR-CG] and the modification of diet in renal disease [GFR-MDRD] formulas) and infant birth weight. Partial correlation coefficients were also calculated.

Results: Maternal GFR-CG (β: 0.73 g/ml/min, p = 0.04) and GFR-MDRD (β: 0.83 g/ml/min, p = 0.04) were associated with infant birth weight in models adjusted for maternal weight in kilograms, preeclampsia, and gestational age at delivery (days). Partial correlation coefficients for the association between infant birth weight and GFR were 0.07 for both formulas. Although the birth weight-GFR association was stronger among the women with preeclampsia, the difference from women without preeclampsia was not statistically significant.

Conclusion: These data support an association between GFR during pregnancy and infant birth weight, and indicate that GFR may confound selected epidemiologic associations.

Citing Articles

Associations of PFAS concentrations during pregnancy and midlife with bone health in midlife: Cross-sectional and prospective findings from Project Viva.

Lin P, Cardenas A, Rokoff L, Rifas-Shiman S, Zhang M, Botelho J Environ Int. 2024; 194:109177.

PMID: 39667063 PMC: 11683763. DOI: 10.1016/j.envint.2024.109177.

Maternal and Paternal Preconception Serum Concentrations of Per and Polyfluoroalkyl Substances in Relation to Birth Outcomes.

Zhang Y, Mustieles V, Martin L, Sun Y, Hillcoat A, Fang X Environ Sci Technol. 2024; 58(6):2683-2692.

PMID: 38290209 PMC: 10924800. DOI: 10.1021/acs.est.3c07954.

Taibl K, Liang D, Dunlop A, Barr D, Smith M, Steenland K Environ Pollut. 2023; 323:121331.

PMID: 36813097 PMC: 10023492. DOI: 10.1016/j.envpol.2023.121331.

Factors Associated with the Severity of Pregnancy-Related Hypertensive Disorder: Significance of Clinical, Laboratory, and Histopathological Features.

An H, Song D, Kim Y, Jo H, Baek J, Kim H Diagnostics (Basel). 2022; 12(9).

PMID: 36140589 PMC: 9498006. DOI: 10.3390/diagnostics12092188.

Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the Project Viva cohort.

Preston E, Hivert M, Fleisch A, Calafat A, Sagiv S, Perng W Environ Int. 2022; 165:107335.

PMID: 35696844 PMC: 9348856. DOI: 10.1016/j.envint.2022.107335.

References

Starling A, Engel S, Richardson D, Baird D, Haug L, Stuebe A . Perfluoroalkyl substances during pregnancy and validated preeclampsia among nulliparous women in the Norwegian Mother and Child Cohort Study. Am J Epidemiol. 2014; 179(7):824-33. PMC: 3969534. DOI: 10.1093/aje/kwt432. View

Magnus P, Irgens L, Haug K, Nystad W, Skjaerven R, Stoltenberg C . Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol. 2006; 35(5):1146-50. DOI: 10.1093/ije/dyl170. View

Spencer E, Appleby P, Davey G, Key T . Validity of self-reported height and weight in 4808 EPIC-Oxford participants. Public Health Nutr. 2002; 5(4):561-5. DOI: 10.1079/PHN2001322. View

Clark S, Youngman L, Palmer A, Parish S, Peto R, Collins R . Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies. Int J Epidemiol. 2003; 32(1):125-30. DOI: 10.1093/ije/dyg023. View

Knopp R, Bergelin R, Wahl P, Walden C . Relationships of infant birth size to maternal lipoproteins, apoproteins, fuels, hormones, clinical chemistries, and body weight at 36 weeks gestation. Diabetes. 1985; 34 Suppl 2:71-7. DOI: 10.2337/diab.34.2.s71. View

Nilsen R, Vollset S, Gjessing H, Skjaerven R, Melve K, Schreuder P . Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatr Perinat Epidemiol. 2009; 23(6):597-608. DOI: 10.1111/j.1365-3016.2009.01062.x. View

Halldorsson T, Rytter D, Haug L, Bech B, Danielsen I, Becher G . Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environ Health Perspect. 2012; 120(5):668-73. PMC: 3346773. DOI: 10.1289/ehp.1104034. View

Duvekot J, Peeters L . Renal hemodynamics and volume homeostasis in pregnancy. Obstet Gynecol Surv. 1994; 49(12):830-9. DOI: 10.1097/00006254-199412000-00007. View

Calafat A, Kuklenyik Z, Reidy J, Caudill S, Tully J, Needham L . Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES). Environ Sci Technol. 2007; 41(7):2237-42. DOI: 10.1021/es062686m. View

10.

Koetje P, Spaan J, Kooman J, Spaanderman M, Peeters L . Pregnancy reduces the accuracy of the estimated glomerular filtration rate based on Cockroft-Gault and MDRD formulas. Reprod Sci. 2010; 18(5):456-62. DOI: 10.1177/1933719110387831. View

11.

Olson J, Shu X, Ross J, Pendergrass T, Robison L . Medical record validation of maternally reported birth characteristics and pregnancy-related events: a report from the Children's Cancer Group. Am J Epidemiol. 1997; 145(1):58-67. DOI: 10.1093/oxfordjournals.aje.a009032. View

12.

Ahmed S, Bentley-Lewis R, Hollenberg N, Graves S, Seely E . A comparison of prediction equations for estimating glomerular filtration rate in pregnancy. Hypertens Pregnancy. 2009; 28(3):243-55. PMC: 3811128. DOI: 10.1080/10641950801986720. View

13.

Johnson D, Jones G, Mathew T, Ludlow M, Doogue M, Jose M . Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: new developments and revised recommendations. Med J Aust. 2012; 197(4):224-5. DOI: 10.5694/mja11.11329. View

14.

Ronningen K, Paltiel L, Meltzer H, Nordhagen R, Lie K, Hovengen R . The biobank of the Norwegian Mother and Child Cohort Study: a resource for the next 100 years. Eur J Epidemiol. 2006; 21(8):619-25. PMC: 1820840. DOI: 10.1007/s10654-006-9041-x. View

15.

Smith M, Moran P, Ward M, Davison J . Assessment of glomerular filtration rate during pregnancy using the MDRD formula. BJOG. 2007; 115(1):109-12. DOI: 10.1111/j.1471-0528.2007.01529.x. View

16.

Chen M, Ha E, Wen T, Su Y, Lien G, Chen C . Perfluorinated compounds in umbilical cord blood and adverse birth outcomes. PLoS One. 2012; 7(8):e42474. PMC: 3411780. DOI: 10.1371/journal.pone.0042474. View

17.

Akahori Y, Masuyama H, Hiramatsu Y . The correlation of maternal uric acid concentration with small-for-gestational-age fetuses in normotensive pregnant women. Gynecol Obstet Invest. 2012; 73(2):162-7. DOI: 10.1159/000332391. View

18.

Duvekot J, Peeters L . Maternal cardiovascular hemodynamic adaptation to pregnancy. Obstet Gynecol Surv. 1994; 49(12 Suppl):S1-14. DOI: 10.1097/00006254-199412011-00001. View

19.

Dunlop W . Serial changes in renal haemodynamics during normal human pregnancy. Br J Obstet Gynaecol. 1981; 88(1):1-9. DOI: 10.1111/j.1471-0528.1981.tb00929.x. View

20.

Zhou H, Chen J, Rissanen T, Korrick S, Hu H, Salonen J . Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome. Epidemiology. 2007; 18(4):461-8. PMC: 3664946. DOI: 10.1097/EDE.0b013e31806462d3. View