Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Postpartum Health in Project Viva: A Prospective Cohort

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2020 Jul 4

PMID 32620010

Citations 7

Authors

Susanna D Mitro

Sharon K Sagiv

Abby F Fleisch

Lindsay M Jaacks

Paige L Williams

Sheryl L Rifas-Shiman

Antonia M Calafat

Marie-France Hivert

Emily Oken

Tamarra M James-Todd

Affiliations

Soon will be listed here.

Abstract

Context: Per- and polyfluoroalkyl substances (PFAS) are environmental chemicals linked to weight gain and type 2 diabetes.

Objective: We examined the extent to which PFAS plasma concentrations during pregnancy were associated with postpartum anthropometry and biomarkers.

Design, Patients, And Measures: We studied women recruited between 1999 and 2002 in the Project Viva prospective cohort with pregnancy plasma concentrations of PFAS, including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and 2-(N-ethyl-perfluorooctane sulfonamide) acetic acid (EtFOSAA). Three-year postpartum anthropometry measurements were available from 786 to 801 women, blood pressure from 761 women, and blood biomarkers from 450 to 454 women. We used multivariable regression to evaluate the association of log2-transformed PFAS with postpartum anthropometry, blood pressure, and blood biomarkers (leptin, adiponectin, sex hormone binding globulin [SHBG], hemoglobin A1c, interleukin-6 [IL-6], C-reactive protein), adjusting for age, prepregnancy body mass index, marital status, race/ethnicity, education, income, smoking, parity, and breastfeeding history.

Results: Pregnancy concentrations of certain PFAS were associated with greater adiposity (eg, 0.4 cm [95% confidence interval [95%CI]: -0.1, 0.9] greater waist circumference per doubling in EtFOSAA; 0.2 cm [95%CI: -0.1, 0.5] greater mid-upper arm circumference per doubling in PFOA; 1.2 mm [95%CI: 0.1, 2.2] thicker sum of subscapular and triceps skinfolds per doubling in PFOS) and higher systolic blood pressure (eg, 1.2 mm Hg [95%CI: 0.3, 2.2] per doubling in PFOS) at 3 years postpartum. Higher EtFOSAA concentrations were also associated with 10.8% higher IL-6 (95%CI: 3.3, 18.9) and 6.1% lower SHBG (95%CI: 0.7, 11.2) per doubling.

Conclusions: Pregnancy concentrations of EtFOSAA, PFOS, and PFOA were associated with adverse postpartum cardiometabolic markers.

Citing Articles

Association between family economic situation and serum PFAS concentration in American adults with hypertension and hyperlipemia.

Zhou X, Wang X, Ou T, Huang L, He B Sci Rep. 2024; 14(1):20799.

PMID: 39242648 PMC: 11379923. DOI: 10.1038/s41598-024-71664-0.

Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort.

Kinkade C, Rivera-Nunez Z, Thurston S, Kannan K, Miller R, Brunner J Environ Health. 2023; 22(1):61.

PMID: 37658449 PMC: 10474772. DOI: 10.1186/s12940-023-01009-3.

Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the Project Viva cohort.

Preston E, Hivert M, Fleisch A, Calafat A, Sagiv S, Perng W Environ Int. 2022; 165:107335.

PMID: 35696844 PMC: 9348856. DOI: 10.1016/j.envint.2022.107335.

Cross-sectional associations between serum PFASs and inflammatory biomarkers in a population exposed to AFFF-contaminated drinking water.

Barton K, Zell-Baran L, DeWitt J, Brindley S, McDonough C, Higgins C Int J Hyg Environ Health. 2022; 240:113905.

PMID: 35065522 PMC: 9394217. DOI: 10.1016/j.ijheh.2021.113905.

Protracted Impairment of Maternal Metabolic Health in Mouse Dams Following Pregnancy Exposure to a Mixture of Low Dose Endocrine-Disrupting Chemicals, a Pilot Study.

Merrill A, Anderson T, Conrad K, Marvin E, James-Todd T, Cory-Slechta D Toxics. 2021; 9(12.

PMID: 34941779 PMC: 8706199. DOI: 10.3390/toxics9120346.

References

Stuebe A, Kleinman K, Gillman M, Rifas-Shiman S, Gunderson E, Rich-Edwards J . Duration of lactation and maternal metabolism at 3 years postpartum. J Womens Health (Larchmt). 2010; 19(5):941-50. PMC: 2924789. DOI: 10.1089/jwh.2009.1660. View

Tsai M, Lin C, Lin C, Chen M, Hsu S, Chien K . Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults. Int J Hyg Environ Health. 2015; 218(5):437-43. DOI: 10.1016/j.ijheh.2015.03.008. View

Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J . Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut. 2019; 247:1055-1063. PMC: 6404528. DOI: 10.1016/j.envpol.2019.01.064. View

Zota A, Geller R, Romano L, Coleman-Phox K, Adler N, Parry E . Association between persistent endocrine-disrupting chemicals (PBDEs, OH-PBDEs, PCBs, and PFASs) and biomarkers of inflammation and cellular aging during pregnancy and postpartum. Environ Int. 2018; 115:9-20. PMC: 5970048. DOI: 10.1016/j.envint.2018.02.044. View

Rosen M, Das K, Rooney J, Abbott B, Lau C, Corton J . PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology. 2017; 387:95-107. PMC: 6129013. DOI: 10.1016/j.tox.2017.05.013. View

Specht I, Hougaard K, Spano M, Bizzaro D, Manicardi G, Lindh C . Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions. Reprod Toxicol. 2012; 33(4):577-583. DOI: 10.1016/j.reprotox.2012.02.008. View

Zhang L, Ren X, Wan B, Guo L . Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ. Toxicol Appl Pharmacol. 2014; 279(3):275-283. DOI: 10.1016/j.taap.2014.06.020. View

Vested A, Ramlau-Hansen C, Olsen S, Bonde J, Kristensen S, Halldorsson T . Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men. Environ Health Perspect. 2013; 121(4):453-8. PMC: 3620740. DOI: 10.1289/ehp.1205118. View

Romano M, Xu Y, Calafat A, Yolton K, Chen A, Webster G . Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding. Environ Res. 2016; 149:239-246. PMC: 4907828. DOI: 10.1016/j.envres.2016.04.034. View

10.

Christensen K, Raymond M, Meiman J . Perfluoroalkyl substances and metabolic syndrome. Int J Hyg Environ Health. 2018; 222(1):147-153. DOI: 10.1016/j.ijheh.2018.08.014. View

11.

van den Dungen M, Murk A, Kok D, Steegenga W . Persistent organic pollutants alter DNA methylation during human adipocyte differentiation. Toxicol In Vitro. 2016; 40:79-87. DOI: 10.1016/j.tiv.2016.12.011. View

12.

Marasco M, Conteh A, Reissaus C, Cupit 5th J, Appleman E, Mirmira R . Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response. Diabetes. 2018; 67(8):1576-1588. PMC: 6054440. DOI: 10.2337/db17-1280. View

13.

Joensen U, Bossi R, Leffers H, Jensen A, Skakkebaek N, Jorgensen N . Do perfluoroalkyl compounds impair human semen quality?. Environ Health Perspect. 2009; 117(6):923-7. PMC: 2702407. DOI: 10.1289/ehp.0800517. View

14.

Egeland G, Skurtveit S, Staff A, Eide G, Daltveit A, Klungsoyr K . Pregnancy-Related Risk Factors Are Associated With a Significant Burden of Treated Hypertension Within 10 Years of Delivery: Findings From a Population-Based Norwegian Cohort. J Am Heart Assoc. 2018; 7(10). PMC: 6015329. DOI: 10.1161/JAHA.117.008318. View

15.

Stuebe A, Rich-Edwards J . The reset hypothesis: lactation and maternal metabolism. Am J Perinatol. 2008; 26(1):81-8. PMC: 3006166. DOI: 10.1055/s-0028-1103034. View

16.

Sagiv S, Rifas-Shiman S, Webster T, Mora A, Harris M, Calafat A . Sociodemographic and Perinatal Predictors of Early Pregnancy Per- and Polyfluoroalkyl Substance (PFAS) Concentrations. Environ Sci Technol. 2015; 49(19):11849-58. PMC: 4638415. DOI: 10.1021/acs.est.5b02489. View

17.

Muka T, Nano J, Jaspers L, Meun C, Bramer W, Hofman A . Associations of Steroid Sex Hormones and Sex Hormone-Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis. Diabetes. 2017; 66(3):577-586. DOI: 10.2337/db16-0473. View

18.

Kato K, Basden B, Needham L, Calafat A . Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals. J Chromatogr A. 2010; 1218(15):2133-7. DOI: 10.1016/j.chroma.2010.10.051. View

19.

Min J, Lee K, Park J, Min K . Perfluorooctanoic acid exposure is associated with elevated homocysteine and hypertension in US adults. Occup Environ Med. 2012; 69(9):658-62. PMC: 3426376. DOI: 10.1136/oemed-2011-100288. View

20.

James-Todd T, Meeker J, Huang T, Hauser R, Ferguson K, Rich-Edwards J . Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors. Environ Int. 2016; 96:118-126. PMC: 5304919. DOI: 10.1016/j.envint.2016.09.009. View