Breast Cancer Stem Cells and the Immune System: Promotion, Evasion and Therapy

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2014 Jul 7

PMID 24997735

Citations 12

Authors

Sarah T Boyle

Marina Kochetkova

Affiliations

Soon will be listed here.

Abstract

Cancer stem cells are believed to be a subset of heterogeneous tumour cells responsible for tumour initiation, growth, local invasion, and metastasis. In breast cancer, numerous factors have been implicated in regulation of cancer stem cells, but there is still a paucity of information regarding precise molecular and cellular mechanisms guiding their pathobiology. Components of both the adaptive and the innate immune system have been shown to play a crucial role in supporting breast cancer growth and spread, and recently some immune mediators, both molecules and cells, have been reported to influence breast cancer stem cell biology. This review summarises a small, pioneering body of evidence for the potentially important function of the "immuniche" in maintaining and supporting breast cancer stem cells.

Citing Articles

Fate decisions of breast cancer stem cells in cancer progression.

Xu H, Zhang F, Gao X, Zhou Q, Zhu L Front Oncol. 2022; 12:968306.

PMID: 36046046 PMC: 9420991. DOI: 10.3389/fonc.2022.968306.

The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity.

Fico F, Santamaria-Martinez A Cancers (Basel). 2020; 12(12).

PMID: 33371274 PMC: 7766255. DOI: 10.3390/cancers12123863.

More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer.

Goralski K, Jackson A, McKeown B, Sinal C Int J Mol Sci. 2019; 20(19).

PMID: 31561459 PMC: 6801800. DOI: 10.3390/ijms20194778.

Expression of chemerin correlates with a poor prognosis in female breast cancer patients.

El-Sagheer G, Gayyed M, Ahmad A, Abd El-Fattah A, Mohamed M Breast Cancer (Dove Med Press). 2018; 10:169-176.

PMID: 30498371 PMC: 6207381. DOI: 10.2147/BCTT.S178181.

Association between inflammation and cancer stem cell phenotype in breast cancer.

Jeong Y, Oh H, Park S, Bong J Oncol Lett. 2018; 15(2):2380-2386.

PMID: 29434947 PMC: 5777276. DOI: 10.3892/ol.2017.7607.

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