Overexpression of MicroRNA-21 and MicroRNA-126 in the Patients of Bronchial Asthma
Overview
Affiliations
MicroRNAs are implicated in an increasing number of diseases and health complications, including asthma. Previous studies have suggested roles for microRNA-21 (miR-21) and microRNA-126 (miR-126) in asthma, although these relationships are incompletely understood. The aim of this study was to further assess the relationship between miR-21, miR-126 and the occurrence and treatment of allergic asthma. Quantitative real-time PCR analyzed expression levels of miR-21 and miR-126 in bronchial epidermal cells from asthma patients treated with (treatment group, n=19) or without (non-treatment group, n=16) inhaled corticosteroids or from non-asthmatic healthy individuals (normal group, n=12). Bronchial epidermal cells were cultured in vitro to determine if there was a relationship between IL-13 and miR-21 and miR-126 expression. Compared to the normal group, miR-21 and miR-126 expression was significantly upregulated in asthma patients regardless of treatment. miR-21 and miR-126 expression was significantly higher in the non-treatment group than the treatment group (P<0.05). In vitro, miR-21 and miR-126 expression increased in bronchial epidermal cells with increasing IL-13 concentration. Because upregulation of miR-126 and miR-21 were associated with occurrence and therapy of allergic asthma, they may be indices of therapeutic effect that are valuable for the evaluation for asthma treatment.
Chen Q, Zheng J, Wang D World J Stem Cells. 2025; 17(2):103599.
PMID: 40061271 PMC: 11885939. DOI: 10.4252/wjsc.v17.i2.103599.
Mao Z, Ding Z, Liu Z, Shi Y, Zhang Q Int Arch Allergy Immunol. 2024; 185(8):775-785.
PMID: 38588656 PMC: 11309074. DOI: 10.1159/000538252.
MiRNA and Exosomal miRNA as New Biomarkers Useful to Phenotyping Severe Asthma.
Soccio P, Moriondo G, Lacedonia D, Tondo P, Pescatore D, Quarato C Biomolecules. 2023; 13(10).
PMID: 37892224 PMC: 10605226. DOI: 10.3390/biom13101542.
Ortega R, Liu B, Persaud S Int J Mol Sci. 2023; 24(13).
PMID: 37445956 PMC: 10342147. DOI: 10.3390/ijms241310777.
Zhang T, Huang P, Qiu C Ann Transl Med. 2022; 10(8):493.
PMID: 35571411 PMC: 9096391. DOI: 10.21037/atm-22-929.