A Comprehensive Analysis of MicroRNAs As Diagnostic Biomarkers for Asthma

Overview

Journal Ther Adv Respir Dis

Publisher Sage Publications

Specialties Pharmacology
Pulmonary Medicine

Date 2020 Dec 28

PMID 33357010

Citations 8

Authors

Li Xu

Minhan Yi

Yun Tan

Zixun Yi

Yuan Zhang

Affiliations

Soon will be listed here.

Abstract

Background: It is unclear whether microRNAs could be a potential diagnostic biomarker for asthma or not. The objective of this study is to figure out the diagnostic value of microRNAs in asthma.

Methods: Literature retrieval, screening of publications, specific data extraction, and quality evaluation were conducted according to the standard criteria. Stata 14.0 software was used to analyze the diagnostic value of microRNA for asthma, including the combined sensitivity (Sen), specificity (Spe), the area under the curve (AUC), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

Results: A total of 72 studies, containing 4143 cases and 2188 controls, were included for this comprehensive analysis. None of the included publications were rated low in quality. We summarized that, compared with controls, more than 100 miRNAs were reported differently expressed in asthma, although the expression trends were inconsistent. Besides, there were five studies among these 72 articles that applied the diagnostic evaluation of microRNAs in asthma. We found that the pooled Sen, Spe, and AUC for the combination of miR-185-5p, miR-155, let-7a, miR-21, miR-320a, miR-1246, miR-144-5p, and miR-1165-3p in asthma were 0.87 (95%CI: 0.72-0.95), 0.84 (95%CI: 0.74-0.91), and 0.93 (95%CI: 0.89-0.94) individually, and the PLR, NLR, and DOR were 5.5 (95%CI: 3.1-9.7), 0.15 (95%CI: 0.07-0.36), and 35 (95%CI: 10-127) in asthma, respectively. In terms of subgroup analyses, we found that the Sen for these combination miRNAs from serum was higher than that in plasma, while the Spe in plasma worked better than that in serum. Furthermore, compared with children, the combination of above miRNAs from adults had higher Spe and similar Sen.

Conclusions: From our analysis, the combination of miR-185-5p, miR-155, let-7a, miR-21, miR-320a, miR-1246, miR-144-5p, and miR-1165-3p from peripheral blood could potentially act as a diagnostic biomarker for asthma.

Citing Articles

miR-21-5p Modulates Airway Inflammation and Epithelial-Mesenchymal Transition Processes in a Mouse Model of Combined Allergic Rhinitis and Asthma Syndrome.

Mao Z, Ding Z, Liu Z, Shi Y, Zhang Q Int Arch Allergy Immunol. 2024; 185(8):775-785.

PMID: 38588656 PMC: 11309074. DOI: 10.1159/000538252.

MicroRNAs in chronic pediatric diseases (Review).

Zhang M, Han Y Exp Ther Med. 2024; 27(3):100.

PMID: 38356668 PMC: 10865459. DOI: 10.3892/etm.2024.12388.

Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma.

Lee J, Wang L, Lin Y, Yang Y, Yu H, Hu Y Sci Rep. 2023; 13(1):6381.

PMID: 37076662 PMC: 10115804. DOI: 10.1038/s41598-023-33663-5.

Blood-Based Biomarkers for Eosinophilic Esophagitis and Concomitant Atopic Diseases: A Look into the Potential of Extracellular Vesicles.

Grueso-Navarro E, Navarro P, Laserna-Mendieta E, Lucendo A, Arias-Gonzalez L Int J Mol Sci. 2023; 24(4).

PMID: 36835081 PMC: 9967575. DOI: 10.3390/ijms24043669.

Analysis of serum exosome microRNAs in the rat model of chronic obstructive pulmonary disease.

Ouyang C, Wang W, Wu D, Wang W, Ye X, Yang Q Am J Transl Res. 2023; 15(1):138-150.

PMID: 36777859 PMC: 9908490.

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