Arginine and Asymmetric Dimethylarginine in Pregnant Women with Major Depression

Overview

Journal Psychosom Med

Specialty Psychiatry

Date 2014 Jul 1

PMID 24979576

Citations 4

Authors

Alexander Raw

Marcia Gallaher

Robert W Powers

Affiliations

Soon will be listed here.

Abstract

Objective: Depression has been associated with vascular dysfunction, which may be of particular relevance in pregnancy. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine play a critical role in vascular function. The objective of this study was to investigate differences in ADMA, SDMA, and L-arginine among pregnant women with major depression compared with pregnant women without depression.

Methods: A case-control study was conducted in 21 depressed pregnant women and 42 matched controls. Maternal plasma ADMA, SDMA, and L-arginine were quantified, as well as C-reactive protein and urine excretion of ADMA, SDMA, L-arginine, and Arginase I.

Results: Plasma L-arginine and ADMA levels were significantly lower in the first trimester in women with depression (mean [standard deviation = 37.0 [9.2] and 0.298 [0.06] μM, respectively) compared with matched controls (42.1 [11.4] and 0.336 [0.08] μM, p = .004 and p = .002, respectively) and across pregnancies (p < .001 both). Depressed pregnant women had higher levels of plasma C-reactive protein (7.5 [3.7] versus 5.1 [4.0] μg/ml, p = .027), but no differences in urine excretion of ADMA, SDMA, or L-arginine, or plasma levels of Arginase I (p > .10).

Conclusions: Pregnant women with depression show lower plasma levels of L-arginine and ADMA. These differences are not explained by urinary excretion or Arginase I levels. The mechanism responsible for the observed differences in depressed pregnant women requires further research.

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References

Meades R, Ayers S . Anxiety measures validated in perinatal populations: a systematic review. J Affect Disord. 2010; 133(1-2):1-15. DOI: 10.1016/j.jad.2010.10.009. View

Boger R, Maas R, Schulze F, Schwedhelm E . Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk. Pharmacol Res. 2009; 60(6):481-7. DOI: 10.1016/j.phrs.2009.07.001. View

Howren M, Lamkin D, Suls J . Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009; 71(2):171-86. DOI: 10.1097/PSY.0b013e3181907c1b. View

Mittermayer F, Kautzky-Willer A, Winzer C, Krzyzanowska K, Prikoszovich T, Demehri S . Elevated concentrations of asymmetric dimethylarginine are associated with deterioration of glucose tolerance in women with previous gestational diabetes mellitus. J Intern Med. 2007; 261(4):392-8. DOI: 10.1111/j.1365-2796.2007.01772.x. View

Bados A, Gomez-Benito J, Balaguer G . The state-trait anxiety inventory, trait version: does it really measure anxiety?. J Pers Assess. 2010; 92(6):560-7. DOI: 10.1080/00223891.2010.513295. View

Backhaus J, Junghanns K, Broocks A, Riemann D, Hohagen F . Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res. 2002; 53(3):737-40. DOI: 10.1016/s0022-3999(02)00330-6. View

Straub H, Adams M, Kim J, Silver R . Antenatal depressive symptoms increase the likelihood of preterm birth. Am J Obstet Gynecol. 2012; 207(4):329.e1-4. DOI: 10.1016/j.ajog.2012.06.033. View

Skouteris H, Wertheim E, Germano C, Paxton S, Milgrom J . Assessing sleep during pregnancy: a study across two time points examining the Pittsburgh Sleep Quality Index and associations with depressive symptoms. Womens Health Issues. 2008; 19(1):45-51. DOI: 10.1016/j.whi.2008.10.004. View

van der Zwan L, Scheffer P, Dekker J, Stehouwer C, Heine R, Teerlink T . Systemic inflammation is linked to low arginine and high ADMA plasma levels resulting in an unfavourable NOS substrate-to-inhibitor ratio: the Hoorn Study. Clin Sci (Lond). 2011; 121(2):71-8. DOI: 10.1042/CS20100595. View

10.

Lakhan S, Vieira K . Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutr J. 2010; 9:42. PMC: 2959081. DOI: 10.1186/1475-2891-9-42. View

11.

Seedat S, Scott K, Angermeyer M, Berglund P, Bromet E, Brugha T . Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys. Arch Gen Psychiatry. 2009; 66(7):785-95. PMC: 2810067. DOI: 10.1001/archgenpsychiatry.2009.36. View

12.

Moyer C, Yang H, Kwawukume Y, Gupta A, Zhu Y, Koranteng I . Optimism/pessimism and health-related quality of life during pregnancy across three continents: a matched cohort study in China, Ghana, and the United States. BMC Pregnancy Childbirth. 2009; 9:39. PMC: 2744663. DOI: 10.1186/1471-2393-9-39. View

13.

Selley M . Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression. J Affect Disord. 2004; 80(2-3):249-56. DOI: 10.1016/S0165-0327(03)00135-6. View

14.

Grigoriadis S, VonderPorten E, Mamisashvili L, Tomlinson G, Dennis C, Koren G . The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry. 2013; 74(4):e321-41. DOI: 10.4088/JCP.12r07968. View

15.

Leiper J . The DDAH-ADMA-NOS pathway. Ther Drug Monit. 2006; 27(6):744-6. DOI: 10.1097/01.ftd.0000179849.42395.11. View

16.

Ix J, Wassel C, Stevens L, Beck G, Froissart M, Navis G . Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration. Clin J Am Soc Nephrol. 2010; 6(1):184-91. PMC: 3022241. DOI: 10.2215/CJN.05030610. View

17.

Rytlewski K, Olszanecki R, Korbut R, Zdebski Z . Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005; 35(1):32-7. DOI: 10.1111/j.1365-2362.2005.01445.x. View

18.

Pinto V, Souza P, Brunini T, Oliveira M, Moss M, Siqueira M . Low plasma levels of L-arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: implications for cardiovascular disease in depressive patients. J Affect Disord. 2012; 140(2):187-92. DOI: 10.1016/j.jad.2012.02.008. View

19.

Berry G, Steiner R . Long-term management of patients with urea cycle disorders. J Pediatr. 2001; 138(1 Suppl):S56-60; discussion S60-1. DOI: 10.1067/mpd.2001.111837. View

20.

Krzyzanowska K, Mittermayer F, Wolzt M, Schernthaner G . Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes. Diabetes Care. 2007; 30(7):1834-9. DOI: 10.2337/dc07-0019. View