The DDAH-ADMA-NOS Pathway

Overview

Journal Ther Drug Monit

Specialty Pharmacology

Date 2006 Jan 13

PMID 16404814

Citations 13

Authors

James M Leiper

Affiliations

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Abstract

An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS),particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.

Citing Articles

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Protein arginine methyltransferases in renal development, injury, repair, and fibrosis.

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Craig A, Mels C, Schutte A, Bollenbach A, Tsikas D, Schwedhelm E Hypertens Res. 2020; 44(1):71-79.

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Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.

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Colonic epithelial cell diversity in health and inflammatory bowel disease.

Parikh K, Antanaviciute A, Fawkner-Corbett D, Jagielowicz M, Aulicino A, Lagerholm C Nature. 2019; 567(7746):49-55.

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