Hesperidin Induces Paraptosis Like Cell Death in Hepatoblastoma, HepG2 Cells: Involvement of ERK1/2 MAPK [corrected]

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jul 1

PMID 24977707

Citations 22

Authors

Silvia Yumnam

Hyeon Soo Park

Mun Ki Kim

Arulkumar Nagappan

Gyeong Eun Hong

Ho Jeong Lee

Won Sup Lee

Eun Hee Kim

Jae Hyeon Cho

Sung Chul Shin

Gon Sup Kim

Affiliations

Soon will be listed here.

Abstract

Hesperidin, a natural flavonoid abundantly present in Citrus is known for its anti-cancer, anti-oxidant and anti-inflammatory properties. In this study we examined the effect of hesperidin on HepG2 cells. HepG2 cells treated with various concentration of hesperidin undergo a distinct type of programed cell death. Cytoplasmic vacuolization, mitochondria and endoplasmic reticulum swelling and uncondensed chromatin were observed in hesperidin treated cells. DNA electrophoresis show lack of DNA fragmentation and western blot analysis demonstrates lack of caspase activation and PARP cleavage. It was observed that hesperidin induced cell death is nonautophagic and also activate mitogen activated protein kinase ERK1/2. Taken together, the data indicate that hesperidin induces paraptosis like cell death in HepG2 cells with the activation of ERK1/2. Thus our finding suggests that hesperidin inducing paraptosis may offer an alternative tool in human liver carcinoma therapy.

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