Exploring Paraptosis As a Therapeutic Approach in Cancer Treatment

Overview

Journal J Biomed Sci

Publisher Biomed Central

Specialty Biology

Date 2024 Nov 4

PMID 39497143

Authors

Ling-Chu Chang

Shih-Kai Chiang

Shuen-Ei Chen

Mien-Chie Hung

Affiliations

Soon will be listed here.

Abstract

A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment.

References

Kessel D, Reiners J . Photodynamic therapy: autophagy and mitophagy, apoptosis and paraptosis. Autophagy. 2020; 16(11):2098-2101. PMC: 7595601. DOI: 10.1080/15548627.2020.1783823. View

Yoon M, Kim E, Lim J, Kwon T, Choi K . Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Free Radic Biol Med. 2009; 48(5):713-26. DOI: 10.1016/j.freeradbiomed.2009.12.016. View

Cao Y, Trillo-Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E . ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019; 10(1):1280. PMC: 6426975. DOI: 10.1038/s41467-019-09263-1. View

Din R, Jiao A, Qiu Y, Mohan A, Yuen K, Wong H . Bortezomib Is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation, and Mitotic Catastrophe. Int J Mol Sci. 2023; 24(19). PMC: 10572992. DOI: 10.3390/ijms241914646. View

Venereau E, Ceriotti C, Bianchi M . DAMPs from Cell Death to New Life. Front Immunol. 2015; 6:422. PMC: 4539554. DOI: 10.3389/fimmu.2015.00422. View

Sperandio S, de Belle I, Bredesen D . An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A. 2000; 97(26):14376-81. PMC: 18926. DOI: 10.1073/pnas.97.26.14376. View

Lanner J, Georgiou D, Joshi A, Hamilton S . Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010; 2(11):a003996. PMC: 2964179. DOI: 10.1101/cshperspect.a003996. View

Kar R, Singha P, Venkatachalam M, Saikumar P . A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. Oncogene. 2009; 28(28):2556-68. PMC: 2717022. DOI: 10.1038/onc.2009.118. View

Mohamed E, Sierra R, Trillo-Tinoco J, Cao Y, Innamarato P, Payne K . The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020; 52(4):668-682.e7. PMC: 7207019. DOI: 10.1016/j.immuni.2020.03.004. View

10.

Chen X, Chen X, Zhang X, Wang L, Cao P, Rajamanickam V . Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells. Redox Biol. 2018; 21:101061. PMC: 6306695. DOI: 10.1016/j.redox.2018.11.019. View

11.

Solovieva M, Shatalin Y, Odinokova I, Krestinina O, Baburina Y, Mishukov A . Disulfiram oxy-derivatives induce entosis or paraptosis-like death in breast cancer MCF-7 cells depending on the duration of treatment. Biochim Biophys Acta Gen Subj. 2022; 1866(9):130184. DOI: 10.1016/j.bbagen.2022.130184. View

12.

Kessel D . Exploring Modes of Photokilling by Hypericin. Photochem Photobiol. 2020; 96(5):1101-1104. DOI: 10.1111/php.13275. View

13.

Aiken C, Kaake R, Wang X, Huang L . Oxidative stress-mediated regulation of proteasome complexes. Mol Cell Proteomics. 2011; 10(5):R110.006924. PMC: 3098605. DOI: 10.1074/mcp.M110.006924. View

14.

Tang T, Liang H, Wei W, Han Y, Cao L, Cong Z . Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma. Mol Biomed. 2023; 4(1):42. PMC: 10656413. DOI: 10.1186/s43556-023-00155-x. View

15.

Gandolfi S, Laubach J, Hideshima T, Chauhan D, Anderson K, Richardson P . The proteasome and proteasome inhibitors in multiple myeloma. Cancer Metastasis Rev. 2017; 36(4):561-584. DOI: 10.1007/s10555-017-9707-8. View

16.

Zou T, Lin Z . The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression. Int J Mol Sci. 2021; 22(11). PMC: 8198665. DOI: 10.3390/ijms22115754. View

17.

Rizvi I, Obaid G, Bano S, Hasan T, Kessel D . Photodynamic therapy: Promoting in vitro efficacy of photodynamic therapy by liposomal formulations of a photosensitizing agent. Lasers Surg Med. 2018; 50(5):499-505. PMC: 7449601. DOI: 10.1002/lsm.22813. View

18.

Mandula J, Chang S, Mohamed E, Jimenez R, Sierra-Mondragon R, Chang D . Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses. Cancer Cell. 2022; 40(10):1145-1160.e9. PMC: 9561067. DOI: 10.1016/j.ccell.2022.08.016. View

19.

Man S, Lv P, Cui J, Liu F, Peng L, Ma L . Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin. Toxicol Appl Pharmacol. 2020; 406:115206. DOI: 10.1016/j.taap.2020.115206. View

20.

Gomez-Pastor R, Burchfiel E, Thiele D . Regulation of heat shock transcription factors and their roles in physiology and disease. Nat Rev Mol Cell Biol. 2017; 19(1):4-19. PMC: 5794010. DOI: 10.1038/nrm.2017.73. View