Supercooling Enables Long-term Transplantation Survival Following 4 Days of Liver Preservation

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2014 Jun 30

PMID 24973919

Citations 72

Authors

Tim A Berendsen

Bote G Bruinsma

Catheleyne F Puts

Nima Saeidi

O Berk Usta

Basak E Uygun

Maria-Louisa Izamis

Mehmet Toner

Martin L Yarmush

Korkut Uygun

Affiliations

Soon will be listed here.

Abstract

The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.

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