VPS35 Parkinson Mutation Impairs Autophagy Via WASH

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2014 Jun 26

PMID 24963965

Citations 13

Authors

Eszter Zavodszky

Matthew N J Seaman

David C Rubinsztein

Affiliations

Soon will be listed here.

Citing Articles

Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration.

Fu C, Yang N, Chuang J, Nakajima N, Iraha S, Roy N Nat Commun. 2024; 15(1):5970.

PMID: 39043666 PMC: 11266608. DOI: 10.1038/s41467-024-50189-0.

Autophagy in Parkinson's Disease.

Nechushtai L, Frenkel D, Pinkas-Kramarski R Biomolecules. 2023; 13(10).

PMID: 37892117 PMC: 10604695. DOI: 10.3390/biom13101435.

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

Rosianu F, Mihaylov S, Eder N, Martiniuc A, Claxton S, Flynn H Life Sci Alliance. 2022; 6(2).

PMID: 36446521 PMC: 9711861. DOI: 10.26508/lsa.202201712.

Mitophagy in depression: Pathophysiology and treatment targets.

Tripathi A, Scaini G, Barichello T, Quevedo J, Pillai A Mitochondrion. 2021; 61:1-10.

PMID: 34478906 PMC: 8962570. DOI: 10.1016/j.mito.2021.08.016.

Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.

Ma K, Fokkens M, Reggiori F, Mari M, Verbeek D Transl Neurodegener. 2021; 10(1):19.

PMID: 34127073 PMC: 8204421. DOI: 10.1186/s40035-021-00243-4.

References

Bi F, Li F, Huang C, Zhou H . Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity. Int J Biol Sci. 2013; 9(2):149-55. PMC: 3572397. DOI: 10.7150/ijbs.5617. View

Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin U . Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014; 23(17):4621-38. PMC: 4119414. DOI: 10.1093/hmg/ddu178. View

Zimprich A, Benet-Pages A, Struhal W, Graf E, Eck S, Offman M . A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet. 2011; 89(1):168-75. PMC: 3135812. DOI: 10.1016/j.ajhg.2011.06.008. View

Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M . The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010; 123(Pt 21):3703-17. PMC: 2964111. DOI: 10.1242/jcs.071472. View

Puri C, Renna M, Bento C, Moreau K, Rubinsztein D . Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 2013; 154(6):1285-99. PMC: 3791395. DOI: 10.1016/j.cell.2013.08.044. View